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Syntheses of dendritic linkers containing chlorambucil residues for the preparation of antibody-multidrug immunoconjugates

Academic Article
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Overview

authors

  • Sun, C. Z.
  • Wirsching, P.
  • Janda, Kim

publication date

  • August 2002

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • A novel dendritic molecule with nine chlorambucil (CBL) residues on the surface and a maleimide moiety at the core terminus was synthesized using a convergent synthetic methodology. This molecule is ready for attachment to single-chain Fv antibodies (scFvs) to form antibody-multidrug immunoconjugates in an effort to study the relevance of drug/antibody molar ratio and the potency of these drug-antibody immunoconjugates. A monomer and a trimer with a similar structural motif were also prepared for comparative purposes.

subject areas

  • Antibodies
  • Chlorambucil
  • Drug Delivery Systems
  • Immunoconjugates
  • Molecular Structure
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(02)00361-x

PubMed ID

  • 12127540
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Additional Document Info

start page

  • 2213

end page

  • 2215

volume

  • 12

issue

  • 16

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