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P300 latency reflects the degree of cognitive decline in dementing illness

Academic Article
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Overview

authors

  • Polich, John
  • Ehlers, Cindy
  • Otis, S.
  • Mandell, A. J.
  • Bloom, Floyd

publication date

  • February 1986

journal

  • Electroencephalography and Clinical Neurophysiology  Journal

abstract

  • An auditory discrimination paradigm was employed to elicit the P3 component of the event-related brain potential (ERP) from 39 demented patients (mean age = 71 years). Component latency was longer in patients who were diagnosed as having primary degenerative dementia and other cognitive impairment disorders compared to age-matched controls. Neurologist ratings of cognitive impairment were significantly correlated with P3 latency values, although no differences in mean latency were obtained between the various categories of dementia. ERP measurement techniques and the interpretation of P3 latency as in index of dementing illness are discussed.

subject areas

  • Aged
  • Aging
  • Cognition Disorders
  • Dementia
  • Electroencephalography
  • Evoked Potentials, Auditory
  • Female
  • Humans
  • Male
  • Reaction Time
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Identity

International Standard Serial Number (ISSN)

  • 0013-4694

Digital Object Identifier (DOI)

  • 10.1016/0013-4694(86)90007-6

PubMed ID

  • 2417814
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Additional Document Info

start page

  • 138

end page

  • 144

volume

  • 63

issue

  • 2

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