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Sonographic monitoring of mass effect in stroke patients treated with hypothermia. Correlation with intracranial pressure and matrix metalloproteinase 2 and 9 expression

Academic Article
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Overview

authors

  • Horstmann, S.
  • Koziol, James
  • Martinez-Torres, F.
  • Nagel, S.
  • Gardner, H.
  • Wagner, S.

publication date

  • January 2009

journal

  • Journal of the Neurological Sciences  Journal

abstract

  • Severe stroke leads to subsequent cerebral oedema. Patients with severe stroke develop midline shift (MLS) which can be measured by transcranial duplex sonography (TCD). We measured MLS with TCD in 30 patients with large infarction in the territory of the middle cerebral artery (MCA). All of the examined patients had intracranial pressure (ICP) measure devices and the ICP at the time of the TCD was recorded. MLS was also determined on CT scan on day 4. Ten of the 30 patients were treated with hypothermia. We also determined matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) in serum by zymography. MLS measured by TCD correlated significantly with MLS on CT. In addition there was a strong correlation between the ICP measured at the time of TCD and MLS. In patients treated with hypothermia MLS was less pronounced. MMP9 and MMP2 showed a characteristic time course and had strong associations with MLS. We confirm earlier reports that TCD is a reliable noninvasive method for serially monitoring patients with intracranial lesions. Hypothermia reduces MMP9 activity as well as MLS. TCD may reduce the need for repetitive CT scans in neurological critically ill patients.

subject areas

  • Aged
  • Female
  • Humans
  • Hypothermia, Induced
  • Intracranial Pressure
  • Male
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
  • Middle Aged
  • Monitoring, Physiologic
  • Stroke
  • Ultrasonography, Doppler, Transcranial
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Research

keywords

  • Cerebrovascular disease
  • Matrix metalloproteinases
  • Neuroradiology
  • Stroke
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Identity

International Standard Serial Number (ISSN)

  • 0022-510X

Digital Object Identifier (DOI)

  • 10.1016/j.jns.2008.08.038

PubMed ID

  • 18834996
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Additional Document Info

start page

  • 75

end page

  • 78

volume

  • 276

issue

  • 1-2

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