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Complexes of activated protein-C with alpha-1-antitrypsin in normal-pregnancy and in severe preeclampsia

Academic Article
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Overview

authors

  • Espana, F.
  • Gilabert, J.
  • Aznar, J.
  • Estelles, A.
  • Kobayashi, T.
  • Griffin, John

publication date

  • May 1991

journal

  • American Journal of Obstetrics and Gynecology  Journal

abstract

  • Protein C is a vitamin K-dependent regulator of blood coagulation. Activated protein C is regulated in plasma in large part by two inhibitors, protein C inhibitor and alpha 1-antitrypsin. Complexes of activated protein C with both inhibitors in plasma samples from subjects with normal or pathologic pregnancy were measured. In normal pregnancy we observed a progressive and significant increase in activated protein C/alpha 1-antitrypsin complex levels, from 9 +/- 3 ng/ml in the first trimester to 16 +/- 3 ng/ml in the third trimester, as well as an increase in alpha 1-antitrypsin plasma levels. In severe preeclampsia, but not in chronic hypertension with superimposed severe preeclampsia, there was a greater increase in activated protein C/alpha 1-antitrypsin levels (25 +/- 10 ng/ml) (p less than 0.001) and a decrease in protein C and protein C inhibitor levels as compared with normal pregnant women at similar gestational ages. These data show an increase in the activation of the protein C pathway in both normal and pathologic pregnancy and provide evidence for an enhancement of thrombin generation in severe preeclampsia compared with chronic hypertension with superimposed severe preeclampsia.

subject areas

  • Adolescent
  • Adult
  • Alanine Transaminase
  • Analysis of Variance
  • Aspartate Aminotransferases
  • Blood Proteins
  • Creatinine
  • Diagnosis, Differential
  • Female
  • Gestational Age
  • Humans
  • Hypertension
  • L-Lactate Dehydrogenase
  • Pre-Eclampsia
  • Pregnancy
  • Pregnancy Complications, Cardiovascular
  • Protein C
  • Protein C Inhibitor
  • Serine Proteinase Inhibitors
  • alpha 1-Antitrypsin
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Research

keywords

  • ALPHA-1-ANTITRYPSIN
  • CHRONIC HYPERTENSION
  • PREECLAMPSIA
  • PREGNANCY
  • PROTEIN-C COMPLEXES
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Identity

International Standard Serial Number (ISSN)

  • 0002-9378

PubMed ID

  • 1852102
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Additional Document Info

start page

  • 1310

end page

  • 1316

volume

  • 164

issue

  • 5

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