P300 in multiple-sclerosis - a preliminary-report

Academic Article

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Overview

authors

• Polich, John
• Romine, J. S.
• Sipe, J. C.
• Aung, M.
• Dalessio, D. J.

publication date

• 1992

journal

• International Journal of Psychophysiology  Journal

abstract

• The P300 component of the event-related brain potential (ERP) elicited with auditory stimuli and pattern-shift visual evoked potentials (VEPs) was obtained from 16 patients with multiple sclerosis (MS) and 16 matched control subjects. P300 latency was significantly longer and component amplitude relatively depressed in the MS patients compared to control subjects. The P100 potential of the VEP also was delayed for both full-field and half-field stimulus conditions in the patients compared to control subjects. The findings suggest that the P300 ERP may reflect the cognitive decline associated with MS.

subject areas

• Adult
• Electroencephalography
• Evoked Potentials, Auditory
• Evoked Potentials, Visual
• Female
• Humans
• Male
• Middle Aged
• Multiple Sclerosis

Research

keywords

• MULTIPLE SCLEROSIS
• P300
• VISUAL EVOKED POTENTIAL

Identity

International Standard Serial Number (ISSN)

• 0167-8760

Digital Object Identifier (DOI)

• 10.1016/0167-8760(92)90006-w

PubMed ID

• 1592668

Additional Document Info

start page

• 155

end page

• 163

volume

• 12

issue

• 2