recent publications
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academic article
- Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., Sanna, P. P., George, O., et al. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals Journal of Clinical Investigation 2015 125:3193-3197 DOI:10.1172/jci79828 PMID:26121746
- Kim, A., Zamora-Martinez, E. R., Edwards, S., Mandyam, C. D. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity Brain Structure & Function 2015 220:1705-1720 DOI:10.1007/s00429-014-0755-3 PMID:24667898 PMCID:PMC4177030
- Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., Koob, G. F. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia Addiction Biology 2015 20:275-284 DOI:10.1111/adb.12120 PMID:24330252 PMCID:PMC4057367
- Cohen, A., Treweek, J., Edwards, S., Leao, R. M., Schulteis, G., Koob, G. F., George, O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats Addiction Biology 2015 20:56-68 DOI:10.1111/adb.12077 PMID:23869743 PMCID:PMC3859819
- Whitfield Jr., T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., Koob, G. F. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake Journal of Neuroscience 2015 35:4296-4305 DOI:10.1523/jneurosci.1978-13.2015 PMID:25762676 PMCID:PMC4355200
- Mazei-Robison, M. S., Appasani, R., Edwards, S., Wee, S., Taylor, S. R., Picciotto, M. R., Koob, G. F., Nestler, E. J. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons PLoS One 2014 9:e95962 DOI:10.1371/journal.pone.0095962 PMID:24755634 PMCID:PMC3995955
- Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., George, O. Addiction as a stress surfeit disorder Neuropharmacology 2014 76:370-382 DOI:10.1016/j.neuropharm2013.05.024 PMID:23747571 PMCID:PMC3830720
- Apkarian, A. V., Neugebauer, V., Koob, G., Edwards, S., Levine, J. D., Ferrari, L., Egli, M., Regunathan, S. Neural mechanisms of pain and alcohol dependence Pharmacology, Biochemistry and Behavior 2013 112:34-41 DOI:10.1016/j.pbb.2013.09.008 PMID:24095683 PMCID:PMC4887744
- Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry 2013 74:520-528 DOI:10.1016/j.biopsych.2013.04.028 PMID:23751206 PMCID:PMC3773286
- Park, P. E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Schulteis, G., Koob, G. F. Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats International Journal of Neuropsychopharmacology 2013 16:1867-1875 DOI:10.1017/s1461145713000308 PMID:23590881 PMCID:PMC3880138
- Edwards, S., Koob, G. F. Escalation of drug self-administration as a hallmark of persistent addiction liability Behavioural Pharmacology 2013 24:356-362 DOI:10.1097/FBP.0b013e3283644d15 PMID:23839030 PMCID:PMC3866817
- Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M., Koob, G. F., Gilpin, N. W. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity Translational Psychiatry 2013 3:e296 DOI:10.1038/tp.2013.70 PMID:23982628 PMCID:PMC3756295
- Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America 2013 110:9036-9041 DOI:10.1073/pnas.1219159110 PMID:23650354 PMCID:PMC3670323
- Barbier, E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Juergens, N., Park, P. E., Misra, K. K., Cheng, K. J., Rice, K. C., Schank, J., Schulteis, G., Koob, G. F., et al. The NK1 receptor antagonist l822429 reduces heroin reinforcement Neuropsychopharmacology 2013 38:976-984 DOI:10.1038/npp.2012.261 PMID:23303056 PMCID:PMC3629386
- Recinto, P., Samant, A. R. H., Chavez, G., Kim, A., Yuan, C. J., Soleiman, M., Grant, Y., Edwards, S., Wee, S., Koob, G. F., George, O., Mandyam, C. D. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration Neuropsychopharmacology 2012 37:1275-1287 DOI:10.1038/npp.2011.315 PMID:22205547 PMCID:PMC3306889
- Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Wee, S., Park, P. E., Schulteis, G., Koob, G. F. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by crf1 receptor antagonism Neuropharmacology 2012 62:1142-1151 DOI:10.1016/j.neuropharm.2011.11.006 PMID:22119954 PMCID:PMC3262951
- Edwards, S., Guerrero, M., Ghoneim, O. M., Roberts, E., Koob, G. F. Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Addiction Biology 2012 17:76-85 DOI:10.1111/j.1369-1600.2010.00291.x PMID:21309953 PMCID:PMC3178679
- Edwards, S., Koob, G. F. Experimental psychiatric illness and drug abuse models: from human to animal, an overview Methods in Molecular Biology 2012 829:31-48 DOI:10.1007/978-1-61779-458-2_2 PMID:22231805 PMCID:PMC3285446
- Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry 2011 54:5195-5204 DOI:10.1021/jm200461m PMID:21692508 PMCID:PMC3142939
- Taffe, M. A., Kotzebue, R. W., Crean, R. D., Crawford, E. F., Edwards, S., Mandyam, C. D. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates Proceedings of the National Academy of Sciences of the United States of America 2010 107:11104-11109 DOI:10.1073/pnas.0912810107 PMID:20534463 PMCID:PMC2890755
- Haussler, D., O'Brien, S. J., Ryder, O. A., Barker, F. K., Clamp, M., Crawford, A. J., Hanner, R., Hanotte, O., Johnson, W. E., McGuire, J. A., Miller, W., Murphy, R. W., et al. Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species Journal of Heredity 2009 100:659-674 DOI:10.1093/jhered/esp086 PMID:19892720 PMCID:PMC2877544
- Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience 2009 29:4846-4857 DOI:10.1523/jneurosci.0563-09.2009 PMID:19369553 PMCID:PMC2688678
- Yusuf, S., Granger, C., Eikelboom, J., Mehta, S., Pogue, J., Tait, P., Behar, S., Benderly, M., Hod, H., Kaplinsky, E., Barrett, N., Bilke, R., et al. Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data Lancet 2002 359:294-302 PMID:11830196
- Czitrom, A. A., Gascoigne, N. R. J., Edwards, S., Waterfield, D. J. Induction of minor alloantigen-specific T cell subsets in vivo: recognition of processed antigen by helper but not by cytotoxic T cell precursors Journal of Immunology 1984 133:33-39 PMID:6202785