recent publications

• academic article

  • Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., Koob, G. F. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia Addiction Biology  2015 20:275-284  DOI:10.1111/adb.12120  PMID:24330252  PMCID:PMC4057367
  • Cohen, A., Treweek, J., Edwards, S., Leao, R. M., Schulteis, G., Koob, G. F., George, O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats Addiction Biology  2015 20:56-68  DOI:10.1111/adb.12077  PMID:23869743  PMCID:PMC3859819
  • Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., Sanna, P. P., George, O., et al. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals Journal of Clinical Investigation  2015 125:3193-3197  DOI:10.1172/jci79828  PMID:26121746
  • Kim, A., Zamora-Martinez, E. R., Edwards, S., Mandyam, C. D. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity Brain Structure & Function  2015 220:1705-1720  DOI:10.1007/s00429-014-0755-3  PMID:24667898  PMCID:PMC4177030
  • Whitfield Jr., T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., Koob, G. F. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake Journal of Neuroscience  2015 35:4296-4305  DOI:10.1523/jneurosci.1978-13.2015  PMID:25762676  PMCID:PMC4355200
  • Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., George, O. Addiction as a stress surfeit disorder Neuropharmacology  2014 76:370-382  DOI:10.1016/j.neuropharm2013.05.024  PMID:23747571  PMCID:PMC3830720
  • Mazei-Robison, M. S., Appasani, R., Edwards, S., Wee, S., Taylor, S. R., Picciotto, M. R., Koob, G. F., Nestler, E. J. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons PLoS One  2014 9:e95962  DOI:10.1371/journal.pone.0095962  PMID:24755634  PMCID:PMC3995955
  • Park, P. E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Schulteis, G., Koob, G. F. Corticotropin-releasing factor (CRF) and alpha 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats International Journal of Neuropsychopharmacology  2013 16:1867-1875  DOI:10.1017/s1461145713000308  PMID:23590881  PMCID:PMC3880138
  • Schlosburg, J. E., Vendruscolo, L. F., Bremer, P. T., Lockner, J. W., Wade, C. L., Nunes, A. A., Stowe, G. N., Edwards, S., Janda, K. D., Koob, G. F. Dynamic vaccine blocks relapse to compulsive intake of heroin Proceedings of the National Academy of Sciences of the United States of America  2013 110:9036-9041  DOI:10.1073/pnas.1219159110  PMID:23650354  PMCID:PMC3670323
  • Edwards, S., Koob, G. F. Escalation of drug self-administration as a hallmark of persistent addiction liability Behavioural Pharmacology  2013 24:356-362  DOI:10.1097/FBP.0b013e3283644d15  PMID:23839030  PMCID:PMC3866817
  • Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry  2013 74:520-528  DOI:10.1016/j.biopsych.2013.04.028  PMID:23751206  PMCID:PMC3773286
  • Apkarian, A. V., Neugebauer, V., Koob, G., Edwards, S., Levine, J. D., Ferrari, L., Egli, M., Regunathan, S. Neural mechanisms of pain and alcohol dependence Pharmacology, Biochemistry and Behavior  2013 112:34-41  DOI:10.1016/j.pbb.2013.09.008  PMID:24095683  PMCID:PMC4887744
  • Barbier, E., Vendruscolo, L. F., Schlosburg, J. E., Edwards, S., Juergens, N., Park, P. E., Misra, K. K., Cheng, K. J., Rice, K. C., Schank, J., Schulteis, G., Koob, G. F., et al. The NK1 receptor antagonist l822429 reduces heroin reinforcement Neuropsychopharmacology  2013 38:976-984  DOI:10.1038/npp.2012.261  PMID:23303056  PMCID:PMC3629386
  • Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M., Koob, G. F., Gilpin, N. W. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity Translational Psychiatry  2013 3:e296  DOI:10.1038/tp.2013.70  PMID:23982628  PMCID:PMC3756295
  • Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K. K., Wee, S., Park, P. E., Schulteis, G., Koob, G. F. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by crf1 receptor antagonism Neuropharmacology  2012 62:1142-1151  DOI:10.1016/j.neuropharm.2011.11.006  PMID:22119954  PMCID:PMC3262951
  • Edwards, S., Guerrero, M., Ghoneim, O. M., Roberts, E., Koob, G. F. Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Addiction Biology  2012 17:76-85  DOI:10.1111/j.1369-1600.2010.00291.x  PMID:21309953  PMCID:PMC3178679
  • Edwards, S., Koob, G. F. Experimental psychiatric illness and drug abuse models: from human to animal, an overview Methods in Molecular Biology  2012 829:31-48  DOI:10.1007/978-1-61779-458-2_2  PMID:22231805  PMCID:PMC3285446
  • Recinto, P., Samant, A. R. H., Chavez, G., Kim, A., Yuan, C. J., Soleiman, M., Grant, Y., Edwards, S., Wee, S., Koob, G. F., George, O., Mandyam, C. D. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration Neuropsychopharmacology  2012 37:1275-1287  DOI:10.1038/npp.2011.315  PMID:22205547  PMCID:PMC3306889
  • Stowe, G. N., Vendruscolo, L. F., Edwards, S., Schlosburg, J. E., Misra, K. K., Schulteis, G., Mayorov, A. V., Zakhari, J. S., Koob, G. F., Janda, K. D. A vaccine strategy that induces protective immunity against heroin Journal of Medicinal Chemistry  2011 54:5195-5204  DOI:10.1021/jm200461m  PMID:21692508  PMCID:PMC3142939
  • Taffe, M. A., Kotzebue, R. W., Crean, R. D., Crawford, E. F., Edwards, S., Mandyam, C. D. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates Proceedings of the National Academy of Sciences of the United States of America  2010 107:11104-11109  DOI:10.1073/pnas.0912810107  PMID:20534463  PMCID:PMC2890755
  • Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience  2009 29:4846-4857  DOI:10.1523/jneurosci.0563-09.2009  PMID:19369553  PMCID:PMC2688678
  • Haussler, D., O'Brien, S. J., Ryder, O. A., Barker, F. K., Clamp, M., Crawford, A. J., Hanner, R., Hanotte, O., Johnson, W. E., McGuire, J. A., Miller, W., Murphy, R. W., et al. Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species Journal of Heredity  2009 100:659-674  DOI:10.1093/jhered/esp086  PMID:19892720  PMCID:PMC2877544
  • Yusuf, S., Granger, C., Eikelboom, J., Mehta, S., Pogue, J., Tait, P., Behar, S., Benderly, M., Hod, H., Kaplinsky, E., Barrett, N., Bilke, R., et al. Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data Lancet  2002 359:294-302  PMID:11830196
  • Czitrom, A. A., Gascoigne, N. R. J., Edwards, S., Waterfield, D. J. Induction of minor alloantigen-specific T cell subsets in vivo: recognition of processed antigen by helper but not by cytotoxic T cell precursors Journal of Immunology  1984 133:33-39  PMID:6202785