recent publications

• academic article

  • Deshpande, R. A., Williams, G. J., Limbo, O., Williams, R. S., Kuhnlein, J., Lee, J. H., Classen, S., Guenther, G., Russell, P., Tainer, J. A., Paull, T. T. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling EMBO Journal  2014 33:482-500  DOI:10.1002/embj.201386100  PMID:24493214  PMCID:PMC3989629
  • Crown, K. N., Savytskyy, O. P., Malik, S. B., Logsdon, J., Williams, R. S., Tainer, J. A., Zolan, M. E. A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation G3-Genes Genomes Genetics  2013 3:1927-1943  DOI:10.1534/g3.113.007906  PMID:24062528  PMCID:PMC3815056
  • Williams, G. J., Williams, R. S., Williams, J. S., Moncalian, G., Arvai, A. S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., Tainer, J. A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Nature Structural & Molecular Biology  2011 18:423-431  DOI:10.1038/nsmb.2038  PMID:21441914  PMCID:PMC3118400
  • Rahal, E. A., Henricksen, L. A., Li, Y. L., Williams, R. S., Tainer, J. A., Dixon, K. Atm regulates mre11-dependent DNA end-degradation and microhomology-mediated end joining Cell Cycle  2010 9:2866-2877  DOI:10.4161/cc.9.14.12408  PMID:20647759  PMCID:PMC3040963
  • Williams, J. S., Williams, R. S., Dovey, C. L., Guenther, G., Tainer, J. A., Russell, P. gamma H2A binds Brc1 to maintain genome integrity during S-phase EMBO Journal  2010 29:1136-1148  DOI:10.1038/emboj.2009.413  PMID:20094029  PMCID:PMC2845269
  • Williams, R. S., Dodson, G. E., Limbo, O., Yamada, Y., Williams, J. S., Guenther, G., Classen, S., Glover, J. N. M., Iwasaki, H., Russell, P., Tainer, J. A. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Cell  2009 139:87-99  DOI:10.1016/j.cell.2009.07.033  PMID:19804755  PMCID:PMC2762657
  • Acharya, S. N., Many, A. M., Schroeder, A. P., Kennedy, F. M., Savytskyy, O. P., Grubb, J. T., Vincent, J. A., Friedle, E. A., Celerin, M., Maillet, D. S., Palmerini, H. J., Greischar, M. A., et al. Coprinus cinereus rad50 mutants reveal an essential structural role for rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination Genetics  2008 180:1889-1907  DOI:10.1534/genetics.108.092775  PMID:18940790  PMCID:PMC2600930
  • Edwards, R. A., Lee, M. S., Tsutakawa, S. E., Williams, R. S., Tainer, J. A., Glover, J. N. M. The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Biochemistry  2008 47:11446-11456  DOI:10.1021/bi801115g  PMID:18842000  PMCID:PMC2654182
  • Williams, R. S., Moncalian, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L. M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J. P., et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair Cell  2008 135:97-109  DOI:10.1016/j.cell.2008.08.017  PMID:18854158  PMCID:PMC2681233
  • Williams, R. S., Williams, J. S., Tainer, J. A. Mre11-rad50-nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire  2007 85:509-520  DOI:10.1139/o07-069  PMID:17713585
  • Zhu, W. G., Williams, R. S., Kodadek, T. A cdc6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor Journal of Biological Chemistry  2000 275:32098-32105  DOI:10.1074/jbc.M001560200  PMID:10896933