recent publications
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academic article
- Deshpande, R. A., Williams, G. J., Limbo, O., Williams, R. S., Kuhnlein, J., Lee, J. H., Classen, S., Guenther, G., Russell, P., Tainer, J. A., Paull, T. T. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling EMBO Journal 2014 33:482-500 DOI:10.1002/embj.201386100 PMID:24493214 PMCID:PMC3989629
- Crown, K. N., Savytskyy, O. P., Malik, S. B., Logsdon, J., Williams, R. S., Tainer, J. A., Zolan, M. E. A mutation in the FHA domain of Coprinus cinereus Nbs1 leads to Spo11-independent meiotic recombination and chromosome segregation G3-Genes Genomes Genetics 2013 3:1927-1943 DOI:10.1534/g3.113.007906 PMID:24062528 PMCID:PMC3815056
- Williams, G. J., Williams, R. S., Williams, J. S., Moncalian, G., Arvai, A. S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., Tainer, J. A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Nature Structural & Molecular Biology 2011 18:423-431 DOI:10.1038/nsmb.2038 PMID:21441914 PMCID:PMC3118400
- Rahal, E. A., Henricksen, L. A., Li, Y. L., Williams, R. S., Tainer, J. A., Dixon, K. Atm regulates mre11-dependent DNA end-degradation and microhomology-mediated end joining Cell Cycle 2010 9:2866-2877 DOI:10.4161/cc.9.14.12408 PMID:20647759 PMCID:PMC3040963
- Williams, J. S., Williams, R. S., Dovey, C. L., Guenther, G., Tainer, J. A., Russell, P. gamma H2A binds Brc1 to maintain genome integrity during S-phase EMBO Journal 2010 29:1136-1148 DOI:10.1038/emboj.2009.413 PMID:20094029 PMCID:PMC2845269
- Williams, R. S., Dodson, G. E., Limbo, O., Yamada, Y., Williams, J. S., Guenther, G., Classen, S., Glover, J. N. M., Iwasaki, H., Russell, P., Tainer, J. A. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Cell 2009 139:87-99 DOI:10.1016/j.cell.2009.07.033 PMID:19804755 PMCID:PMC2762657
- Acharya, S. N., Many, A. M., Schroeder, A. P., Kennedy, F. M., Savytskyy, O. P., Grubb, J. T., Vincent, J. A., Friedle, E. A., Celerin, M., Maillet, D. S., Palmerini, H. J., Greischar, M. A., et al. Coprinus cinereus rad50 mutants reveal an essential structural role for rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombination Genetics 2008 180:1889-1907 DOI:10.1534/genetics.108.092775 PMID:18940790 PMCID:PMC2600930
- Edwards, R. A., Lee, M. S., Tsutakawa, S. E., Williams, R. S., Tainer, J. A., Glover, J. N. M. The bard1 c-terminal domain structure and interactions with polyadenylation factor cstf-50 Biochemistry 2008 47:11446-11456 DOI:10.1021/bi801115g PMID:18842000 PMCID:PMC2654182
- Williams, R. S., Moncalian, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L. M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J. P., et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair Cell 2008 135:97-109 DOI:10.1016/j.cell.2008.08.017 PMID:18854158 PMCID:PMC2681233
- Williams, R. S., Williams, J. S., Tainer, J. A. Mre11-rad50-nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire 2007 85:509-520 DOI:10.1139/o07-069 PMID:17713585
- Zhu, W. G., Williams, R. S., Kodadek, T. A cdc6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor Journal of Biological Chemistry 2000 275:32098-32105 DOI:10.1074/jbc.M001560200 PMID:10896933