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A jun-binding protein related to a putative tumor-suppressor

Academic Article
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Overview

authors

  • Monteclaro, F. S.
  • Vogt, Peter K.

publication date

  • July 1993

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • A lambda gt11 cDNA library of chicken embryo fibroblasts was screened with biotinylated Jun protein to identify Jun-binding clones. Eight such clones were isolated; one contains a gene referred to as jif-1 that is homologous to the putative tumor suppressor gene QM. jif-1 codes for a protein of 25 kDa that binds to the leucine zipper of viral and cellular Jun. The Jif-1 protein also binds to itself. Jif-1 does not contain a leucine zipper, and it does not bind to the 12-O-tetradecanoylphorbol 13-acetate response element DNA sequence. Complex formation of Jif-1 with Jun inhibits DNA binding and reduces transactivation by Jun. Addition of Fos protein to Jun-Jif-1 complexes restores DNA-binding activity. These observations suggest that Jif-1 is a negative regulator of Jun.

subject areas

  • Amino Acid Sequence
  • Animals
  • Avian Proteins
  • Carrier Proteins
  • Chick Embryo
  • Fibroblasts
  • Gene Library
  • Genes, Tumor Suppressor
  • Leucine Zippers
  • Molecular Sequence Data
  • Plasmids
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Regulatory Sequences, Nucleic Acid
  • Ribosomal Proteins
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Transcriptional Activation
  • Tumor Suppressor Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.90.14.6726

PubMed ID

  • 8341691
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Additional Document Info

start page

  • 6726

end page

  • 6730

volume

  • 90

issue

  • 14

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