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Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected-cells

Academic Article
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Overview

authors

  • Briese, T.
  • de la Torre, Juan
  • Lewis, A.
  • Ludwig, H.
  • Lipkin, W. I.

publication date

  • December 1992

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

subject areas

  • Borna disease virus
  • Cell Nucleus
  • Cells, Cultured
  • Humans
  • In Vitro Techniques
  • Protein Biosynthesis
  • RNA Viruses
  • RNA, Messenger
  • RNA, Viral
  • Transcription, Genetic
  • Virus Diseases
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Research

keywords

  • BEHAVIORAL DISORDERS
  • CENTRAL NERVOUS SYSTEM INFECTION
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.89.23.11486

PubMed ID

  • 1454837
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Additional Document Info

start page

  • 11486

end page

  • 11489

volume

  • 89

issue

  • 23

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