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Germinal center reaction

Academic Article
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Overview

authors

  • McHeyzer-Williams, L. J.
  • Driver, D. J.
  • McHeyzer-Williams, Michael G.

publication date

  • January 2001

journal

  • Current Opinion in Hematology  Journal

abstract

  • The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity. The main purpose of the germinal center reaction is the development of B-cell memory through iterative cycles of somatic antigen receptor diversification and the selection of B cells with receptors of best fit. Recent studies provide insight into the regulation of these complex processes in vivo with new information on the cellular organization of the memory B-cell compartment.

subject areas

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Germinal Center
  • Humans
  • Lymphocyte Cooperation
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 1065-6251

Digital Object Identifier (DOI)

  • 10.1097/00062752-200101000-00010

PubMed ID

  • 11138628
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Additional Document Info

start page

  • 52

end page

  • 59

volume

  • 8

issue

  • 1

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