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Induction of transcription factor ap-1 by adenovirus e1a-protein and camp

Academic Article
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Overview

authors

  • Mueller, Ulrich
  • Roberts, M. P.
  • Engel, D. A.
  • Doerfler, W.
  • Shenk, T.

publication date

  • December 1989

journal

  • Genes & Development  Journal

abstract

  • Treatment of adenovirus-infected mouse S49 cells with cAMP analogs leads to the transcriptional induction of early viral genes. E1A proteins and cAMP work in synergy to activate several of these genes. We now demonstrate that the transcription factor AP-1 is modestly induced by cAMP in S49 cells and induced to significantly higher levels by cAMP in the presence of E1A proteins. Cytoplasmic levels of c-fos and junB mRNAs are rapidly increased by cAMP, and the induction is substantially stronger in the presence of E1A protein. The AP-1 activity binds efficiently to both AP-1 and activating transcription factor (ATF)/cAMP response element binding protein (CREB)-binding sites present in E1A-inducible promoters and presumably plays a role in the transcriptional activation of adenovirus genes by E1A proteins and cAMP.

subject areas

  • Adenovirus Early Proteins
  • Animals
  • Base Sequence
  • Binding, Competitive
  • Bucladesine
  • Cell Line
  • Cyclic AMP
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • Genes
  • Mice
  • Molecular Sequence Data
  • Oncogene Proteins, Viral
  • Protein Kinases
  • Proto-Oncogene Proteins c-jun
  • RNA, Messenger
  • Transcription Factors
  • Transcription, Genetic
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Identity

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.3.12a.1991

PubMed ID

  • 2559873
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Additional Document Info

start page

  • 1991

end page

  • 2002

volume

  • 3

issue

  • 12A

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