Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Regulation of immunity by lysosphingolipids and their g protein - coupled receptors

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Goetzl, E. J.
  • Rosen, Hugh

publication date

  • December 2004

journal

  • Journal of Clinical Investigation  Journal

abstract

  • T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections suggests that this system is a promising target for new forms of immunotherapy.

subject areas

  • Animals
  • B-Lymphocytes
  • Disease Models, Animal
  • Humans
  • Immunity
  • Receptors, G-Protein-Coupled
  • Receptors, Lysosphingolipid
  • Sphingolipids
  • T-Lymphocytes
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci200423704

PubMed ID

  • 15578083
scroll to property group menus

Additional Document Info

start page

  • 1531

end page

  • 1537

volume

  • 114

issue

  • 11

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support