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Activated protein c correlates inversely with thrombin levels in resting healthy individuals

Academic Article
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Overview

authors

  • Fernandez, J. A.
  • Petaja, J.
  • Gruber, A.
  • Griffin, John

publication date

  • September 1997

journal

  • American Journal of Hematology  Journal

abstract

  • To study whether the circulating anticoagulant, activated protein C (APC), could be a regulator of thrombin activity in basal physiological conditions, fibrinopeptide A and activated protein C levels were determined in samples from 40 healthy individuals. There was a significant inverse correlation between the fibrinopeptide A and APC levels (Spearman rank correlation R = -0.487; P = 0.0023). Because of well-known mechanisms by which decreasing APC levels could cause increased thrombin formation, we suggest that APC may downregulate thrombin activity in subjects with normal protein C levels. Regulation of thrombin formation in health is likely significant for maintaining vascular patency but its molecular mechanisms are poorly understood. The current data suggest that a single physiological anticoagulant, namely APC, may be a significant regulator of procoagulant thrombin activity.

subject areas

  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Protein C
  • Rest
  • Thrombin
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Research

keywords

  • anticoagulants
  • fibrinopeptide A
  • protein C
  • thrombin
  • venous thrombosis
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Identity

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/(sici)1096-8652(199709)56:1<29::aid-ajh6>3.0.co;2-4

PubMed ID

  • 9298864
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Additional Document Info

start page

  • 29

end page

  • 31

volume

  • 56

issue

  • 1

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