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Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte

Academic Article
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Overview

authors

  • Guidotti, Luca
  • Borrow, P.
  • Brown, A.
  • McClary, H.
  • Koch, R.
  • Chisari, Francis

publication date

  • May 1999

journal

  • Journal of Experimental Medicine  Journal

abstract

  • We have previously shown that interferon and tumor necrosis factor noncytopathically abolish hepatitis B virus (HBV) replication from the hepatocyte and kidney tubular epithelial cells in vivo. Here we show that a persistent lymphocytic choriomeningitis virus (LCMV) infection is cleared from the hepatocyte noncytopathically when the same cytokines are induced in the liver by antigen-nonspecific stimuli. These results indicate that, like HBV, LCMV is also susceptible to intracellular inactivation by cytokine-induced antiviral mechanisms that are operative in the hepatocyte. In contrast, LCMV is not cleared from intrahepatic nonparenchymal cells or splenocytes, indicating that, unlike the hepatocyte, these cells do not produce the factors required to inactivate LCMV. Antiviral mechanisms like these may have evolved to maintain the functional integrity of vital organs in the face of massive infection.

subject areas

  • Adenoviridae
  • Alanine Transaminase
  • Animals
  • Antigens, CD
  • Cytokines
  • Gene Expression
  • Interferons
  • Interleukins
  • Kidney Tubules
  • Liver
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • RNA, Viral
  • Spleen
  • T-Lymphocytes
  • Tumor Necrosis Factor-alpha
  • Viral Proteins
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Research

keywords

  • cytokines
  • hepatocyte
  • lymphocytic choriomeningitis virus noncytopathic clearance
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.189.10.1555

PubMed ID

  • 10330434
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Additional Document Info

start page

  • 1555

end page

  • 1564

volume

  • 189

issue

  • 10

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