An intramolecular 2+3 cycloaddition route to fused 5-heterosubstituted tetrazoles

Academic Article
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publication date

  • 2001

abstract

  • [reaction: see text] Fused 5-heterotetrazole ring systems are synthesized in high yield via intramolecular [2 + 3] cycloadditions of organic azides and heteroatom-substituted nitriles. Cyanates, thiocyanates, and cyanamides are all competent dipolarophiles for this reaction. A variety of scaffolds are tolerated when the new enclosed ring is five- or six-membered.