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Studies on the total synthesis of formamicin: synthesis of the C(1)-C(11) fragment

Academic Article
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Overview

authors

  • Powell, N. A.
  • Roush, William

publication date

  • February 2001

journal

  • Organic Letters  Journal

abstract

  • [figure: see text] An efficient and highly concise synthesis of 6, corresponding to the C(1)-C(11) fragment of formamicin (1), has been accomplished by a route utilizing a diastereoselective lactate aldol reaction to set the C(6) tertiary ether and the TES-OTf mediated transketalization of the C(6) tertiary methoxymethyl ether and the C(25) PMB ether to set the seven-membered methylene acetal unit (see 37-->38).

subject areas

  • Actinomycetales
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Macrolides
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol0069610

PubMed ID

  • 11428037
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Additional Document Info

start page

  • 453

end page

  • 456

volume

  • 3

issue

  • 3

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