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Pap 9704, a korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine a(2a) receptor stimulation in mice

Academic Article
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Overview

authors

  • Kwon, Y. S.
  • Nabeshima, T.
  • Shin, E. J.
  • Chun, W.
  • Jhoo, J. H.
  • Jhoo, W. K.
  • Wie, N. B.
  • Jang, Choon-Gon
  • Chung, H.
  • Sung, Y. E.
  • Kim, H. C.

publication date

  • June 2004

journal

  • Biological & Pharmaceutical Bulletin  Journal

abstract

  • The effect of PAP 9704, a traditional prescription in Korea consisting of Polygala tenuifolia, Acorus gramineus, and Poria cocos at a ratio of 1:1:1 (dry weight), on methamphetamine (MA)-induced hyperlocomotion was examined in mice. The increased locomotor activity induced by MA (1 mg/kg/d, i.p. x 7) was significantly attenuated by co-administration with PAP 9704 (100 or 200 mg/kg/d, p.o. x 7) in a dose dependent manner. Consistently, it was found that the hyperlocomotor activity occurred in parallel with the expression of striatal fos-related antigen immunoreactivity. The adenosine A(2A) receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1.0 mg/kg, i.p.), significantly reversed the pharmacological action of PAP 9704 in a dose related manner, but the adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) and the A(2B) receptor antagonist alloxazine (1.5 or 3.0 mg/kg, i.p.) did not significantly affect this pharmacological action. Our results suggest that PAP 9704 prevents MA-induced hyperlocomotion, at least in part, via the stimulation of the adenosine A(2A) receptor.

subject areas

  • Animals
  • Hyperkinesis
  • Korea
  • Locomotion
  • Male
  • Methamphetamine
  • Mice
  • Mice, Inbred BALB C
  • Plant Preparations
  • Plants, Medicinal
  • Receptor, Adenosine A2A
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Research

keywords

  • PAP 9704
  • adnosine A(2A) receptor
  • fos-related antigen immunoreactivity
  • locomotor activity
  • methamphetamine
  • striatum
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Identity

International Standard Serial Number (ISSN)

  • 0918-6158

Digital Object Identifier (DOI)

  • 10.1248/bpb.27.906

PubMed ID

  • 15187444
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Additional Document Info

start page

  • 906

end page

  • 909

volume

  • 27

issue

  • 6

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