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Event-related brain potentials in individuals at high and low-risk for developing alcoholism - failure to replicate

Academic Article
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Overview

authors

  • Polich, John
  • Bloom, Floyd

publication date

  • June 1988

journal

  • Alcoholism-Clinical and Experimental Research  Journal

abstract

  • Event-related brain potentials (ERPs) were used to compare young men having a positive paternal family history for alcoholism (FHP) with carefully matched control subjects having no family history for alcoholism (FHN). The P300 ERP component was obtained from all subjects (n = 10/group) with a complex auditory paradigm before and on two occasions after they received a placebo drink which they were told might contain alcohol. The procedures employed replicated those of a previous study in which FHP subjects showed diminished P300 potentials compared to FHN subjects under the placebo as well as ethanol consumption conditions--a finding which raised the possibility that the P300 ERP component might be a biological marker for subjects at high risk to develop alcoholism. No differences between the family history groups were obtained for the P300 or any other ERP component using the replication procedures. Both groups demonstrated a decrease in P300 amplitude across trial blocks in a similar fashion suggesting that habituation effects may have diminished the ERP response.

subject areas

  • Adult
  • Alcohol Drinking
  • Alcoholism
  • Electroencephalography
  • Ethanol
  • Evoked Potentials, Auditory
  • Humans
  • Male
  • Reaction Time
  • Risk Factors
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Identity

International Standard Serial Number (ISSN)

  • 0145-6008

Digital Object Identifier (DOI)

  • 10.1111/j.1530-0277.1988.tb00210.x

PubMed ID

  • 3044165
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Additional Document Info

start page

  • 368

end page

  • 373

volume

  • 12

issue

  • 3

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