Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Giabbai, B.
  • Sidobre, S. P.
  • Crispin, Max
  • Sanchez-Ruiz, Y.
  • Bachi, A.
  • Kronenberg, M.
  • Wilson, Ian
  • Degano, M.

publication date

  • July 2005

journal

  • Journal of Immunology  Journal

abstract

  • NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.

subject areas

  • Animals
  • Antigens, CD1
  • Antigens, CD1d
  • Cell Line
  • Complementarity Determining Regions
  • Crystallography, X-Ray
  • Drosophila melanogaster
  • Killer Cells, Natural
  • Ligands
  • Lymphocyte Activation
  • Mice
  • Models, Molecular
  • Phosphatidylcholines
  • Protein Binding
  • Protein Isoforms
  • Receptors, Antigen, T-Cell, alpha-beta
  • Recombinant Proteins
  • Surface Properties
  • T-Lymphocyte Subsets
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 16002697
scroll to property group menus

Additional Document Info

start page

  • 977

end page

  • 984

volume

  • 175

issue

  • 2

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support