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Viral infection of neurons can depress neurotransmitter mRNA levels without histologic injury

Academic Article
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Overview

authors

  • Lipkin, W. I.
  • Battenberg, E. L. F.
  • Bloom, Floyd
  • Oldstone, Michael

publication date

  • 1988

journal

  • Brain Research  Journal

abstract

  • Neonatal mice inoculated with lymphocytic choriomeningitis virus (LCMV) have non-lytic persistent neuronal infection and disturbed behavior. We now show that LCMV replicates in neurons containing the neurotransmitter somatostatin without morphologic evidence of injury and that persistent neuronal LCMV infection in mice is attended by a decrease in brain levels of somatostatin mRNA. Brain levels of mRNA for another neurotransmitter peptide, cholecystokinin, are not decreased. These data are the first to localize a virus to a specific neurotransmitter-containing cell during in vivo infection and suggest that persistent viral infections could cause neurologic or psychiatric diseases through selective effects on brain levels of neurotransmitter mRNAs.

subject areas

  • Animals
  • Lymphocytic Choriomeningitis
  • Mice
  • Mice, Inbred Strains
  • Neurons
  • RNA, Messenger
  • Somatostatin
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(88)90779-2

PubMed ID

  • 2908027
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Additional Document Info

start page

  • 333

end page

  • 339

volume

  • 451

issue

  • 1-2

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