recent publications
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academic article
- Liu, T., Fu, G., Luo, X., Liu, Y., Wang, Y., Wang, R. E., Schultz, P. G., Wang, F. Rational design of antibody protease inhibitors Journal of the American Chemical Society 2015 137:4042-4045 DOI:10.1021/ja5130786 PMID:25775396
- Paster, W., Bruger, A. M., Katsch, K., Gregoire, C., Roncagalli, R., Fu, G., Gascoigne, N. R. J., Nika, K., Cohnen, A., Feller, S. M., Simister, P. C., Molder, K. C., et al. A THEMIS:SHP1 complex promotes T-cell survival EMBO Journal 2015 34:393-409 DOI:10.15252/embj.201387725 PMID:25535246 PMCID:PMC4339124
- Rybakin, V., Westernberg, L., Fu, G., Kim, H. O., Ampudia, J., Sauer, K., Gascoigne, N. R. J. Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire PLoS One 2014 9 DOI:10.1371/journal.pone.0114320 PMID:25500569 PMCID:PMC4264757
- Wei, N., Shi, Y., Truong, L. N., Fisch, K. M., Xu, T., Gardiner, E., Fu, G., Hsu, Y. S. O., Kishi, S., Su, A. I., Wu, X., Yang, X. L. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage Molecular Cell 2014 56:323-332 DOI:10.1016/j.molcel.2014.09.006 PMID:25284223 PMCID:PMC4224670
- Fu, G., Rybakin, V., Brzostek, J., Paster, W., Acuto, O., Gascoigne, N. R. J. Fine-tuning T cell receptor signaling to control T cell development Trends in Immunology 2014 35:311-318 DOI:10.1016/j.it.2014.05.003 PMID:24951034 PMCID:PMC4119814
- Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., Yang, X. L. tRNA synthetase counteracts c-Myc to develop functional vasculature Elife 2014 3:e02349 DOI:10.7554/eLife.02349 PMID:24940000 PMCID:PMC4057782
- Kong, K. F., Fu, G., Zhang, Y., Yokosuka, T., Casas, J., Canonigo-Balancio, A. J., Becart, S., Kim, G., Yates III, J. R., Kronenberg, M., Saito, T., Gascoigne, N. R. J., et al. Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function Nature Immunology 2014 15:465-472 DOI:10.1038/ni.2866 PMID:24705298 PMCID:PMC4040250
- Nabekura, T., Kanaya, M., Shibuya, A., Fu, G., Gascoigne, N. R. J., Lanier, L. L. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection Immunity 2014 40:225-234 DOI:10.1016/j.immuni.2013.12.011 PMID:24440149 PMCID:PMC3943894
- Casas, J., Brzostek, J., Zarnitsyna, V. I., Hong, J. S., Wei, Q., Hoerter, J. A. H., Fu, G., Ampudia, J., Zamoyska, R., Zhu, C., Gascoigne, N. R. J. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor Nature Communications 2014 5:5624 DOI:10.1038/ncomms6624 PMID:25427562 PMCID:PMC4248239
- Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development Nature 2013 504:441-445 DOI:10.1038/nature12718 PMID:24226767 PMCID:PMC3977001
- Mukherjee, S., Rigaud, S., Seok, S. C., Fu, G., Prochenka, A., Dworkin, M., Gascoigne, N. R. J., Vieland, V. J., Sauer, K., Das, J. In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness PLoS One 2013 8:e73937 DOI:10.1371/journal.pone.0073937 PMID:24066087 PMCID:PMC3774804
- Paster, W., Brockmeyer, C., Fu, G., Simister, P. C., de Wet, B., Martinez-Riano, A., Hoerter, J. A. H., Feller, S. M., Wulfing, C., Gascoigne, N. R. J., Acuto, O. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development Journal of Immunology 2013 190:3749-3756 DOI:10.4049/jimmunol.1203389 PMID:23460737 PMCID:PMC3607403
- Fu, G., Hu, J. F., Niederberger-Magnenat, N., Rybakin, V., Casas, J., Yachi, P. P., Feldstein, S., Ma, B., Hoerter, J. A. H., Ampudia, J., Rigaud, S., Lambolez, F., et al. Protein kinase C η is required for T cell activation and homeostatic proliferation Science Signaling 2011 4:ra84 DOI:10.1126/scisignal.2002058 PMID:22155788 PMCID:PMC3242502
- Brockmeyer, C., Paster, W., Pepper, D., Tan, C. P., Trudgian, D. C., McGowan, S., Fu, G., Gascoigne, N. R. J., Acuto, O., Salek, M. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component Journal of Biological Chemistry 2011 286:7535-7547 DOI:10.1074/jbc.M110.201236 PMID:21189249 PMCID:PMC3045008
- Fu, G., Gascoigne, N. R. J. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry Journal of Immunological Methods 2009 350:194-199 DOI:10.1016/j.jim.2009.07.009 PMID:19647745 PMCID:PMC2782925
- Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J. F., et al. Themis controls thymocyte selection through regulation of t cell antigen receptor-mediated signaling Nature Immunology 2009 10:848-856 DOI:10.1038/ni.1766 PMID:19597499 PMCID:PMC2757056
- Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C., Wulfing, C. Spatiotemporal patterning during t cell activation is highly diverse Science Signaling 2009 2:ra15 DOI:10.1126/scisignal.2000199 PMID:19351954 PMCID:PMC2694444
- Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet 2000 355:337-345 PMID:10665552