recent publications

• academic article

  • Liu, T., Fu, G., Luo, X., Liu, Y., Wang, Y., Wang, R. E., Schultz, P. G., Wang, F. Rational design of antibody protease inhibitors Journal of the American Chemical Society  2015 137:4042-4045  DOI:10.1021/ja5130786  PMID:25775396
  • Paster, W., Bruger, A. M., Katsch, K., Gregoire, C., Roncagalli, R., Fu, G., Gascoigne, N. R. J., Nika, K., Cohnen, A., Feller, S. M., Simister, P. C., Molder, K. C., et al. A THEMIS:SHP1 complex promotes T-cell survival EMBO Journal  2015 34:393-409  DOI:10.15252/embj.201387725  PMID:25535246  PMCID:PMC4339124
  • Rybakin, V., Westernberg, L., Fu, G., Kim, H. O., Ampudia, J., Sauer, K., Gascoigne, N. R. J. Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire PLoS One  2014 9  DOI:10.1371/journal.pone.0114320  PMID:25500569  PMCID:PMC4264757
  • Wei, N., Shi, Y., Truong, L. N., Fisch, K. M., Xu, T., Gardiner, E., Fu, G., Hsu, Y. S. O., Kishi, S., Su, A. I., Wu, X., Yang, X. L. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage Molecular Cell  2014 56:323-332  DOI:10.1016/j.molcel.2014.09.006  PMID:25284223  PMCID:PMC4224670
  • Fu, G., Rybakin, V., Brzostek, J., Paster, W., Acuto, O., Gascoigne, N. R. J. Fine-tuning T cell receptor signaling to control T cell development Trends in Immunology  2014 35:311-318  DOI:10.1016/j.it.2014.05.003  PMID:24951034  PMCID:PMC4119814
  • Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., Yang, X. L. tRNA synthetase counteracts c-Myc to develop functional vasculature Elife  2014 3:e02349  DOI:10.7554/eLife.02349  PMID:24940000  PMCID:PMC4057782
  • Kong, K. F., Fu, G., Zhang, Y., Yokosuka, T., Casas, J., Canonigo-Balancio, A. J., Becart, S., Kim, G., Yates III, J. R., Kronenberg, M., Saito, T., Gascoigne, N. R. J., et al. Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function Nature Immunology  2014 15:465-472  DOI:10.1038/ni.2866  PMID:24705298  PMCID:PMC4040250
  • Nabekura, T., Kanaya, M., Shibuya, A., Fu, G., Gascoigne, N. R. J., Lanier, L. L. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection Immunity  2014 40:225-234  DOI:10.1016/j.immuni.2013.12.011  PMID:24440149  PMCID:PMC3943894
  • Casas, J., Brzostek, J., Zarnitsyna, V. I., Hong, J. S., Wei, Q., Hoerter, J. A. H., Fu, G., Ampudia, J., Zamoyska, R., Zhu, C., Gascoigne, N. R. J. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor Nature Communications  2014 5:5624  DOI:10.1038/ncomms6624  PMID:25427562  PMCID:PMC4248239
  • Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development Nature  2013 504:441-445  DOI:10.1038/nature12718  PMID:24226767  PMCID:PMC3977001
  • Mukherjee, S., Rigaud, S., Seok, S. C., Fu, G., Prochenka, A., Dworkin, M., Gascoigne, N. R. J., Vieland, V. J., Sauer, K., Das, J. In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness PLoS One  2013 8:e73937  DOI:10.1371/journal.pone.0073937  PMID:24066087  PMCID:PMC3774804
  • Paster, W., Brockmeyer, C., Fu, G., Simister, P. C., de Wet, B., Martinez-Riano, A., Hoerter, J. A. H., Feller, S. M., Wulfing, C., Gascoigne, N. R. J., Acuto, O. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development Journal of Immunology  2013 190:3749-3756  DOI:10.4049/jimmunol.1203389  PMID:23460737  PMCID:PMC3607403
  • Fu, G., Hu, J. F., Niederberger-Magnenat, N., Rybakin, V., Casas, J., Yachi, P. P., Feldstein, S., Ma, B., Hoerter, J. A. H., Ampudia, J., Rigaud, S., Lambolez, F., et al. Protein kinase C η is required for T cell activation and homeostatic proliferation Science Signaling  2011 4:ra84  DOI:10.1126/scisignal.2002058  PMID:22155788  PMCID:PMC3242502
  • Brockmeyer, C., Paster, W., Pepper, D., Tan, C. P., Trudgian, D. C., McGowan, S., Fu, G., Gascoigne, N. R. J., Acuto, O., Salek, M. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component Journal of Biological Chemistry  2011 286:7535-7547  DOI:10.1074/jbc.M110.201236  PMID:21189249  PMCID:PMC3045008
  • Fu, G., Gascoigne, N. R. J. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry Journal of Immunological Methods  2009 350:194-199  DOI:10.1016/j.jim.2009.07.009  PMID:19647745  PMCID:PMC2782925
  • Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J. F., et al. Themis controls thymocyte selection through regulation of t cell antigen receptor-mediated signaling Nature Immunology  2009 10:848-856  DOI:10.1038/ni.1766  PMID:19597499  PMCID:PMC2757056
  • Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C., Wulfing, C. Spatiotemporal patterning during t cell activation is highly diverse Science Signaling  2009 2:ra15  DOI:10.1126/scisignal.2000199  PMID:19351954  PMCID:PMC2694444
  • Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet  2000 355:337-345  PMID:10665552