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Delineation of suppressor and helper activity within the okt4-defined lymphocyte-t subset in human newborns

Academic Article
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Overview

authors

  • Jacoby, D. R.
  • Oldstone, Michael

publication date

  • 1983

journal

  • Journal of Immunology  Journal

abstract

  • Lymphocytes taken from the cord blood of newborns have active suppressor activity. Using in vitro PWM-stimulated cocultures, unfractionated T cells from newborns potently suppressed the expected immunoglobulin G (IgG) synthesis of their mothers' peripheral blood lymphocytes (PBL). Using positive and negative selection techniques, we characterized the active suppressor cell as expressing the OKT4+T8- phenotype. This cord blood lymphocyte subset suppressed maternal IgG synthesis after depletion of maternal suppressor cells, implicating the ability of newborn T cells to suppress directly rather than by inducing adult suppressor activity. Sublethal amounts (1500 rad) of gamma-irradiation fully abrogated the suppressor activity of cord blood T lymphocytes. Radioresistant cord T cells provided T cell help. Irradiation of cord OKT4+ and OKT8+ populations and their subsequent culture with maternal B cells determined that helper activity was a radioresistant subpopulation of the OKT4+ subset. These results indicate significant differences in the functional properties of T cell subsets from adults and newborns. Population studies determined that cord blood lymphocytes had a greater proportion of OKT4+ cells and lower proportion of OKT8+ cells than PBL from unrelated adults. The mothers tested had similar proportions of OKT4+ cells as their babies, and these levels are significantly higher than those of unrelated adults.

subject areas

  • Adult
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Female
  • Fetal Blood
  • Humans
  • Immunity, Maternally-Acquired
  • Immunoglobulin G
  • Infant, Newborn
  • Lymphocyte Activation
  • Lymphocyte Cooperation
  • Phenotype
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Regulatory
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 6225798
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Additional Document Info

start page

  • 1765

end page

  • 1770

volume

  • 131

issue

  • 4

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