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The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity

Academic Article
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Overview

authors

  • Wensky, A.
  • Marcondes, Maria Cecilia
  • Lafaille, J. J.

publication date

  • September 2001

journal

  • Journal of Immunology  Journal

abstract

  • It has become increasingly apparent in studies of mutant mice and observations of disease that cytokine production by fully committed effector T cells within the Th1 and Th2 phenotype can vary within each group. This can potentially influence the type and effectiveness of a given immune response. The factors responsible for inducing variable Th1 and Th2 subtype responses have not been well established. Using transgenic mice expressing the myelin basic protein-specific TCR, we demonstrate here that two distinct populations of Th2 cells that are characterized primarily by differential IL-4 and IL-5 expression levels can be generated depending upon the levels of IFN-gamma present at the time of priming. We also demonstrate that populations expressing high levels of IL-4 relative to IL-5 vs those with intermediate levels of IL-4 relative to IL-5 are stable and possess distinct effector functions in an experimental autoimmune encephalomyelitis model.

subject areas

  • Adoptive Transfer
  • Animals
  • Autoimmune Diseases
  • Autoimmunity
  • Encephalomyelitis, Autoimmune, Experimental
  • Gene Expression Profiling
  • Homeodomain Proteins
  • Interferon-gamma
  • Interleukin-4
  • Interleukin-5
  • Lymphokines
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Myelin Basic Protein
  • Phenotype
  • Receptors, Antigen, T-Cell, alpha-beta
  • Specific Pathogen-Free Organisms
  • Th1 Cells
  • Th2 Cells
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 11544291
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Additional Document Info

start page

  • 3074

end page

  • 3081

volume

  • 167

issue

  • 6

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