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Integrin αvβ3 antagonists promote tumor-regression by inducing apoptosis of angiogenic blood-vessels

Academic Article
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Overview

related to degree

  • Hu, Tianhua, Ph.D. in Biology, Scripps Research 1991 - 1997

authors

  • Brooks, P. C.
  • Montgomery, A. M. P.
  • Rosenfeld, M.
  • Reisfeld, Ralph
  • Hu, Tianhua
  • Klier, G.
  • Cheresh, D. A.

publication date

  • December 1994

journal

  • Cell  Journal

abstract

  • A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of integrin alpha v beta 3 disrupts ongoing angiogenesis on the chick chorioallantoic membrane (CAM). This leads to the rapid regression of histologically distinct human tumors transplanted onto the CAM. Induction of angiogenesis by a tumor or cytokine promotes vascular cell entry into the cell cycle and expression of integrin alpha v beta 3. After angiogenesis is initiated, antagonists of this integrin induce apoptosis of the proliferative angiogenic vascular cells, leaving preexisting quiescent blood vessels unaffected. We demonstrate therefore that ligation of integrin alpha v beta 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors.

subject areas

  • Allantois
  • Animals
  • Apoptosis
  • Blood Vessels
  • Chick Embryo
  • Chorion
  • Humans
  • Integrins
  • Neoplasm Transplantation
  • Neoplasms
  • Neovascularization, Pathologic
  • Receptors, Cytoadhesin
  • Receptors, Vitronectin
  • Tumor Cells, Cultured
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(94)90007-8

PubMed ID

  • 7528107
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Additional Document Info

start page

  • 1157

end page

  • 1164

volume

  • 79

issue

  • 7

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