Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Integrin αvβ3 antagonists promote tumor-regression by inducing apoptosis of angiogenic blood-vessels

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Hu, Tianhua, Ph.D. in Biology, Scripps Research 1991 - 1997

authors

  • Brooks, P. C.
  • Montgomery, A. M. P.
  • Rosenfeld, M.
  • Reisfeld, Ralph
  • Hu, Tianhua
  • Klier, G.
  • Cheresh, D. A.

publication date

  • December 1994

journal

  • Cell  Journal

abstract

  • A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of integrin alpha v beta 3 disrupts ongoing angiogenesis on the chick chorioallantoic membrane (CAM). This leads to the rapid regression of histologically distinct human tumors transplanted onto the CAM. Induction of angiogenesis by a tumor or cytokine promotes vascular cell entry into the cell cycle and expression of integrin alpha v beta 3. After angiogenesis is initiated, antagonists of this integrin induce apoptosis of the proliferative angiogenic vascular cells, leaving preexisting quiescent blood vessels unaffected. We demonstrate therefore that ligation of integrin alpha v beta 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors.

subject areas

  • Allantois
  • Animals
  • Apoptosis
  • Blood Vessels
  • Chick Embryo
  • Chorion
  • Humans
  • Integrins
  • Neoplasm Transplantation
  • Neoplasms
  • Neovascularization, Pathologic
  • Receptors, Cytoadhesin
  • Receptors, Vitronectin
  • Tumor Cells, Cultured
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(94)90007-8

PubMed ID

  • 7528107
scroll to property group menus

Additional Document Info

start page

  • 1157

end page

  • 1164

volume

  • 79

issue

  • 7

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support