recent publications
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academic article
- Yoshikawa, T., Wu, J., Otsuka, M., Kishikawa, T., Ohno, M., Shibata, C., Takata, A., Han, F., Kang, Y. J., Chen, C. Y. A., Shyu, A. B., Han, J., et al. ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression Nucleic Acids Research 2015 43:7577-7589 DOI:10.1093/nar/gkv728 PMID:26187994 PMCID:PMC4551943
- Kang, Y. J., Bang, B. R., Han, K. H., Hong, L., Shim, E. J., Ma, J. H., Lerner, R. A., Otsuka, M. Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling Nature Communications 2015 6:8371 DOI:10.1038/ncomms9371 PMID:26381214 PMCID:PMC4576739
- Kang, Y. J., Bang, B. R., Otsuka, M., Otsu, K. Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage Journal of Immunology 2015 194:4759-4766 DOI:10.4049/jimmunol.1402954 PMID:25888643 PMCID:PMC4417423
- Ma, J., Bang, B. R., Lu, J., Eun, S. Y., Otsuka, M., Croft, M., Tobias, P., Han, J., Takeuchi, O., Akira, S., Karin, M., Yagita, H., et al. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation Science Signaling 2013 6:ra87 DOI:10.1126/scisignal.2004431 PMID:24084649 PMCID:PMC4004444
- Yoshikawa, T., Otsuka, M., Kishikawa, T., Takata, A., Ohno, M., Shibata, C., Kang, Y. J., Yoshida, H., Koike, K. Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model PLoS One 2013 8:e71969 DOI:10.1371/journal.pone.0071969 PMID:24023722 PMCID:PMC3759383
- Shim, E. J., Bang, B. R., Kang, S. G., Ma, J., Otsuka, M., Kang, J., Stahl, M., Han, J., Xiao, C., Vallance, B. A., Kang, Y. J. Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections Journal of Immunology 2013 191:2764-2770 DOI:10.4049/jimmunol.1300908 PMID:23918973 PMCID:PMC3770349
- Takata, A., Otsuka, M., Yoshikawa, T., Kishikawa, T., Hikiba, Y., Obi, S., Goto, T., Kang, Y. J., Maeda, S., Yoshida, H., Omata, M., Asahara, H., et al. MicroRNA-140 acts as a liver tumor suppressor by controlling NF-kappaB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression Hepatology 2013 57:162-170 DOI:10.1002/hep.26011 PMID:22898998 PMCID:PMC3521841
- Kojima, K., Takata, A., Vadnais, C., Otsuka, M., Yoshikawa, T., Akanuma, M., Kondo, Y., Kang, Y. J., Kishikawa, T., Kato, N., Xie, Z. F., Zhang, W. P. J., et al. Microrna122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma Nature Communications 2011 2:338 DOI:10.1038/ncomms1345 PMID:21654638
- Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L. X., Huang, Z., Wu, X. R., Zhang, D. W., Vallance, B. A., Tobias, P. S., Han, J. H. Epithelial p38 alpha controls immune cell recruitment in the colonic mucosa PLoS Pathogens 2010 6:e1000934 DOI:10.1371/journal.ppat.1000934 PMID:20532209 PMCID:PMC2880565
- Otsuka, M., Kang, Y. J., Ren, J. L., Jiang, H., Wang, Y., Omata, M., Han, J. Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease Gastroenterology 2010 138:1255-1265 DOI:10.1053/j.gastro.2010.01.005 PMID:20080092 PMCID:PMC2846963
- Kang, Y. J., Chen, J. M., Otsuka, M., Mols, J., Ren, S. X., Wang, Y. B., Han, J. H. Macrophage deletion of p38 alpha partially impairs lipopolysaccharide-induced cellular activation Journal of Immunology 2008 180:5075-5082 PMID:18354233
- Otsuka, M., Zheng, M., Hayashi, M., Lee, J. D., Yoshino, O., Lin, S., Han, J. Impaired microrna processing causes corpus luteum insufficiency and infertility in mice Journal of Clinical Investigation 2008 118:1944-1954 DOI:10.1172/jci33680 PMID:18398510 PMCID:PMC2289794
- Kang, Y. J., Kusler, B., Otsuka, M., Hughes, M., Suzuki, N., Suzuki, S., Yeh, W. C., Akira, S., Han, J., Jones, P. P. Calcineurin negatively regulates tlr-mediated activation pathways Journal of Immunology 2007 179:4598-4607 PMID:17878357
- Otsuka, M., Jing, Q., Georgel, P., New, L., Chen, J. M., Mols, J., Kang, Y. J., Jiang, Z. F., Du, X., Cook, R., Das, S. C., Pattnaik, A. K., et al. Hypersusceptibility to vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and mir93 expression Immunity 2007 27:123-134 DOI:10.1016/j.immuni.2007.05.014 PMID:17613256
- Kang, Y. J., Kim, S. O., Shimada, S., Otsuka, M., Seit-Nebi, A., Kwon, B. S., Watts, T. H., Han, J. H. Cell surface 4-1bbl mediates sequential signaling pathways 'downstream' of tlr and is required for sustained tnf production in macrophages Nature Immunology 2007 8:601-609 DOI:10.1038/ni1471 PMID:17496895