recent publications

• academic article

  • Yoshikawa, T., Wu, J., Otsuka, M., Kishikawa, T., Ohno, M., Shibata, C., Takata, A., Han, F., Kang, Y. J., Chen, C. Y. A., Shyu, A. B., Han, J., et al. ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression Nucleic Acids Research  2015 43:7577-7589  DOI:10.1093/nar/gkv728  PMID:26187994  PMCID:PMC4551943
  • Kang, Y. J., Bang, B. R., Han, K. H., Hong, L., Shim, E. J., Ma, J. H., Lerner, R. A., Otsuka, M. Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling Nature Communications  2015 6:8371  DOI:10.1038/ncomms9371  PMID:26381214  PMCID:PMC4576739
  • Kang, Y. J., Bang, B. R., Otsuka, M., Otsu, K. Tissue-specific regulation of p38α-mediated inflammation in Con A-induced acute liver damage Journal of Immunology  2015 194:4759-4766  DOI:10.4049/jimmunol.1402954  PMID:25888643  PMCID:PMC4417423
  • Ma, J., Bang, B. R., Lu, J., Eun, S. Y., Otsuka, M., Croft, M., Tobias, P., Han, J., Takeuchi, O., Akira, S., Karin, M., Yagita, H., et al. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation Science Signaling  2013 6:ra87  DOI:10.1126/scisignal.2004431  PMID:24084649  PMCID:PMC4004444
  • Yoshikawa, T., Otsuka, M., Kishikawa, T., Takata, A., Ohno, M., Shibata, C., Kang, Y. J., Yoshida, H., Koike, K. Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model PLoS One  2013 8:e71969  DOI:10.1371/journal.pone.0071969  PMID:24023722  PMCID:PMC3759383
  • Shim, E. J., Bang, B. R., Kang, S. G., Ma, J., Otsuka, M., Kang, J., Stahl, M., Han, J., Xiao, C., Vallance, B. A., Kang, Y. J. Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections Journal of Immunology  2013 191:2764-2770  DOI:10.4049/jimmunol.1300908  PMID:23918973  PMCID:PMC3770349
  • Takata, A., Otsuka, M., Yoshikawa, T., Kishikawa, T., Hikiba, Y., Obi, S., Goto, T., Kang, Y. J., Maeda, S., Yoshida, H., Omata, M., Asahara, H., et al. MicroRNA-140 acts as a liver tumor suppressor by controlling NF-kappaB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression Hepatology  2013 57:162-170  DOI:10.1002/hep.26011  PMID:22898998  PMCID:PMC3521841
  • Kojima, K., Takata, A., Vadnais, C., Otsuka, M., Yoshikawa, T., Akanuma, M., Kondo, Y., Kang, Y. J., Kishikawa, T., Kato, N., Xie, Z. F., Zhang, W. P. J., et al. Microrna122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma Nature Communications  2011 2:338  DOI:10.1038/ncomms1345  PMID:21654638
  • Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L. X., Huang, Z., Wu, X. R., Zhang, D. W., Vallance, B. A., Tobias, P. S., Han, J. H. Epithelial p38 alpha controls immune cell recruitment in the colonic mucosa PLoS Pathogens  2010 6:e1000934  DOI:10.1371/journal.ppat.1000934  PMID:20532209  PMCID:PMC2880565
  • Otsuka, M., Kang, Y. J., Ren, J. L., Jiang, H., Wang, Y., Omata, M., Han, J. Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease Gastroenterology  2010 138:1255-1265  DOI:10.1053/j.gastro.2010.01.005  PMID:20080092  PMCID:PMC2846963
  • Kang, Y. J., Chen, J. M., Otsuka, M., Mols, J., Ren, S. X., Wang, Y. B., Han, J. H. Macrophage deletion of p38 alpha partially impairs lipopolysaccharide-induced cellular activation Journal of Immunology  2008 180:5075-5082  PMID:18354233
  • Otsuka, M., Zheng, M., Hayashi, M., Lee, J. D., Yoshino, O., Lin, S., Han, J. Impaired microrna processing causes corpus luteum insufficiency and infertility in mice Journal of Clinical Investigation  2008 118:1944-1954  DOI:10.1172/jci33680  PMID:18398510  PMCID:PMC2289794
  • Kang, Y. J., Kusler, B., Otsuka, M., Hughes, M., Suzuki, N., Suzuki, S., Yeh, W. C., Akira, S., Han, J., Jones, P. P. Calcineurin negatively regulates tlr-mediated activation pathways Journal of Immunology  2007 179:4598-4607  PMID:17878357
  • Otsuka, M., Jing, Q., Georgel, P., New, L., Chen, J. M., Mols, J., Kang, Y. J., Jiang, Z. F., Du, X., Cook, R., Das, S. C., Pattnaik, A. K., et al. Hypersusceptibility to vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and mir93 expression Immunity  2007 27:123-134  DOI:10.1016/j.immuni.2007.05.014  PMID:17613256
  • Kang, Y. J., Kim, S. O., Shimada, S., Otsuka, M., Seit-Nebi, A., Kwon, B. S., Watts, T. H., Han, J. H. Cell surface 4-1bbl mediates sequential signaling pathways 'downstream' of tlr and is required for sustained tnf production in macrophages Nature Immunology  2007 8:601-609  DOI:10.1038/ni1471  PMID:17496895