Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Specific binding of cytotactin to sulfated glycolipids

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Crossin, Kathryn
  • Edelman, Gerald

publication date

  • December 1992

journal

  • Journal of Neuroscience Research  Journal

abstract

  • The binding of the glial glycoprotein, cytotactin, to a variety of purified glycolipids was examined. Clear-cut evidence was found for binding of radiolabeled cytotactin to sulfatides purified from bovine brain, but the molecule did not bind to gangliosides or cerebrosides. The sulfatide binding was sensitive to pH and ionic strength and was dependent on the presence of divalent cations. Binding was inhibited by purified unlabeled cytotactin, by polyclonal antibodies to cytotactin, and by several monosaccharides and polysaccharides. It was not inhibited by fibronectin, a chondroitin sulfate proteoglycan, or the HNK-1 monoclonal antibody, all of which are known to bind to cytotactin. These findings raise the possibilities that sulfated glycolipids may function as cellular receptors for cytotactin and that binding by sulfatides may modulate the varied effects of cytotactin on cellular processes.

subject areas

  • Animals
  • Antibodies
  • Autoradiography
  • Brain
  • Cell Adhesion Molecules, Neuronal
  • Chick Embryo
  • Chromatography, Thin Layer
  • Extracellular Matrix Proteins
  • Gangliosides
  • Glycolipids
  • Hydrogen-Ion Concentration
  • Iodine Radioisotopes
  • Kinetics
  • Monosaccharides
  • Nerve Tissue Proteins
  • Polysaccharides
  • Protein Binding
  • Sulfoglycosphingolipids
  • Tenascin
scroll to property group menus

Research

keywords

  • ADHESION
  • EXTRACELLULAR MATRIX
  • HEMAGGLUTINATION
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0360-4012

Digital Object Identifier (DOI)

  • 10.1002/jnr.490330416

PubMed ID

  • 1282934
scroll to property group menus

Additional Document Info

start page

  • 631

end page

  • 638

volume

  • 33

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support