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Autoallergic reactions induced by procainamide

Academic Article
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Overview

authors

  • Tan, Eng
  • Rubin, R. L.

publication date

  • 1984

journal

  • Journal of Allergy and Clinical Immunology  Journal

abstract

  • Procainamide has a high propensity for the induction of an autoimmune response. The immune response is highly selective and the autoantibodies so induced are directed against nuclear histones. Acetylator phenotypes play an important role in the immune response, with slow acetylators developing antihistone antibodies much sooner than fast acetylators. In the early detection of drug-induced lupus syndromes, the finding of antihistone antibodies in the absence of other types of antinuclear antibodies greatly aids in establishing the diagnosis.

subject areas

  • Acetylation
  • Antibodies, Antinuclear
  • Antibody Formation
  • Antibody Specificity
  • Autoantibodies
  • Autoimmune Diseases
  • Fluorescent Antibody Technique
  • Histones
  • Humans
  • Lupus Erythematosus, Systemic
  • Phenotype
  • Procainamide
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Identity

International Standard Serial Number (ISSN)

  • 0091-6749

Digital Object Identifier (DOI)

  • 10.1016/0091-6749(84)90117-9

PubMed ID

  • 6386937
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Additional Document Info

start page

  • 631

end page

  • 634

volume

  • 74

issue

  • 4

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