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Serum ribonuclease-activity in cancer-patients

Academic Article
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Overview

authors

  • Kottel, R. H.
  • Hoch, S. O.
  • Parsons, R. G.
  • Hoch, James

publication date

  • 1978

journal

  • British Journal of Cancer  Journal

abstract

  • A study was made of the levels of ribonuclease (RNase) in human serum, using 2 independently collected banks of samples from Scripps Clinic and Research Foundation and the Mayo Clinic, each bank representing more than 100 individuals. These serum samples originated from a cross-section of normal individuals, smokers, patients with benign tumours, and patients with a variety of neoplasms. Elevated levels of serum RNase occurred in 68% of the samples from individuals with malignant disease. Elevated levels also occurred in 24% of the samples from individuals with benign tumours and in 38% of the smoker controls from the Mayo Clinic serum bank. Using ion-exchange chromatography, pooled sera from normal individuals and cancer patients were fractionated by differential salt elution. Each pool showed 2 distinct peaks of RNase activity, and both peaks were elevated to the same degree in the cancer serum pools. Similar results were obtained after thin-layer-gel isoelectric focusing of both normal and cancer sera; no new species of RNase could be detected in the sera of patients with malignant diseases. The results suggested a generalized nonspecific increase in serum RNase in these patients.

subject areas

  • Chromatography, DEAE-Cellulose
  • Clinical Enzyme Tests
  • Humans
  • Isoelectric Focusing
  • Neoplasms
  • Ribonucleases
  • Statistics as Topic
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Identity

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/bjc.1978.199

PubMed ID

  • 698043
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Additional Document Info

start page

  • 280

end page

  • 286

volume

  • 38

issue

  • 2

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