A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

Academic Article

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Overview

authors

• Garner, A. L.
• Janda, Kim

publication date

• 2011

journal

• Chemical Communications  Journal

abstract

• Using our recently disclosed fluorescence-based assay to monitor acyltransferase activity, the first non-peptidic, small molecule antagonists of ghrelin O-acyltransferase (GOAT), a potential anti-obesity and anti-diabetes target, have been discovered. Each exhibits micromolar inhibition of the enzyme, and may be useful probes for future study of the ghrelin-GOAT system.

subject areas

• Acyltransferases
• Amino Acid Sequence
• Drug Evaluation, Preclinical
• Enzyme Inhibitors
• Ghrelin
• Molecular Sequence Data
• Small Molecule Libraries

Identity

International Standard Serial Number (ISSN)

• 1359-7345

Digital Object Identifier (DOI)

• 10.1039/c1cc11817j

PubMed ID

• 21594284

Additional Document Info

start page

• 7512

end page

• 7514

volume

• 47

issue

• 26