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A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

Academic Article
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Overview

authors

  • Garner, A. L.
  • Janda, Kim

publication date

  • 2011

journal

  • Chemical Communications  Journal

abstract

  • Using our recently disclosed fluorescence-based assay to monitor acyltransferase activity, the first non-peptidic, small molecule antagonists of ghrelin O-acyltransferase (GOAT), a potential anti-obesity and anti-diabetes target, have been discovered. Each exhibits micromolar inhibition of the enzyme, and may be useful probes for future study of the ghrelin-GOAT system.

subject areas

  • Acyltransferases
  • Amino Acid Sequence
  • Drug Evaluation, Preclinical
  • Enzyme Inhibitors
  • Ghrelin
  • Molecular Sequence Data
  • Small Molecule Libraries
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Identity

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c1cc11817j

PubMed ID

  • 21594284
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Additional Document Info

start page

  • 7512

end page

  • 7514

volume

  • 47

issue

  • 26

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