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Physiological significance of a peripheral tissue circadian clock

Academic Article
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Overview

authors

  • Lamia, Katja
  • Storch, K. F.
  • Weitz, C. J.

publication date

  • September 2008

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Mammals have circadian clocks in peripheral tissues, but there is no direct evidence of their physiological importance. Unlike the suprachiasmatic nucleus clock that is set by light and drives rest-activity and fasting-feeding cycles, peripheral clocks are set by daily feeding, suggesting that at least some contribute metabolic regulation. The liver plays a well known role in glucose homeostasis, and we report here that mice with a liver-specific deletion of Bmal1, an essential clock component, exhibited hypoglycemia restricted to the fasting phase of the daily feeding cycle, exaggerated glucose clearance, and loss of rhythmic expression of hepatic glucose regulatory genes. We conclude that the liver clock is important for buffering circulating glucose in a time-of-day-dependent manner. Our findings suggest that the liver clock contributes to homeostasis by driving a daily rhythm of hepatic glucose export that counterbalances the daily cycle of glucose ingestion resulting from the fasting-feeding cycle.

subject areas

  • ARNTL Transcription Factors
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Circadian Rhythm
  • Gene Expression Regulation
  • Glucose
  • Homeostasis
  • Liver
  • Mice
  • Mice, Mutant Strains
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Research

keywords

  • glucose homeostasis
  • liver
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Identity

PubMed Central ID

  • PMC2532700

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0806717105

PubMed ID

  • 18779586
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Additional Document Info

start page

  • 15172

end page

  • 15177

volume

  • 105

issue

  • 39

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