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Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone BXSB mice

Academic Article
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Overview

authors

  • Pollard, Kenneth Michael
  • Pearson, D. L.
  • Hultman, P.
  • Deane, T. N.
  • Lindh, U.
  • Kono, Dwight

publication date

  • January 2001

journal

  • Environmental Health Perspectives  Journal

abstract

  • The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence of environmental exposure on autoimmune disease in sensitive populations. We tested this premise by exposing autoimmune-prone BXSB and the nonautoimmune C57BL/6 mice to the heavy metal mercury. Although both strains express a nonsusceptible H-2 haplotype, exposure to mercury accelerated systemic autoimmunity in both male and female BXSB mice, whereas the C57BL/6 mice were resistant. The subclasses of antichromatin antibodies elicited in BXSB mice by mercury exposure were more consistent with the predominant Th1-type response of idiopathic disease than with the Th2-type response found in mercury-induced autoimmunity (HgIA). The appearance and magnitude of both humoral and cellular features of systemic autoimmunity correlated with the mercury dose. Furthermore, environmentally relevant tissue levels of mercury were associated with exacerbated systemic autoimmunity. These studies demonstrate that xenobiotic exposure can accelerate spontaneous systemic autoimmunity, and they support the possibility that low-level xenobiotic exposure enhances susceptibility to systemic autoimmunity in genetically susceptible individuals.

subject areas

  • Animals
  • Antibody Formation
  • Autoantibodies
  • Autoimmunity
  • Chromatin
  • Disease Models, Animal
  • Female
  • Genetic Predisposition to Disease
  • Lupus Erythematosus, Systemic
  • Male
  • Mercury
  • Mice
  • Mice, Inbred C57BL
  • Xenobiotics
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Research

keywords

  • autoantibodies
  • autoimmunity
  • in vivo animal models
  • lupus
  • rodent
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Identity

PubMed Central ID

  • PMC1242047

International Standard Serial Number (ISSN)

  • 0091-6765

Digital Object Identifier (DOI)

  • 10.2307/3434917

PubMed ID

  • 11171521
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Additional Document Info

start page

  • 27

end page

  • 33

volume

  • 109

issue

  • 1

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