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Control of mhc restriction by tcr v-alpha cdr1 and cdr2

Academic Article
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Overview

authors

  • Sim, B. C.
  • Zerva, L.
  • Greene, M. I.
  • Gascoigne, Nicholas

publication date

  • August 1996

journal

  • Science  Journal

abstract

  • Individual T cell receptor (TCR) Valpha elements are expressed preferentially in CD4 or CD8 peripheral T cell subsets. The closely related Valpha3.1 and Valpha3.2 elements show reciprocal selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed mutants of a Valpha3.1 gene were used to show that individual residues in either the complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection from the CD4 subset to the CD8 subset. Thus, the germline-encoded Valpha elements are a major influence on major histocompatibility class complex (MHC) restriction, most likely by a preferential interaction with one or the other class of MHC molecule.

subject areas

  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Mutagenesis, Site-Directed
  • Receptors, Antigen, T-Cell, alpha-beta
  • Transgenes
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.273.5277.963

PubMed ID

  • 8688082
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Additional Document Info

start page

  • 963

end page

  • 966

volume

  • 273

issue

  • 5277

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