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Mice lacking 5-ht7 receptors show specific impairments in contextual learning

Academic Article
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Overview

authors

  • Roberts, Amanda
  • Krucker, T.
  • Levy, C. L.
  • Slanina, K. A.
  • Sutcliffe, J. Gregor
  • Hedlund, Peter

publication date

  • April 2004

journal

  • European Journal of Neuroscience  Journal

abstract

  • Using 5-HT(7) receptor knockout mice it has been shown that the 5-HT(7) receptor is the main mediator of serotonin-induced hypothermia but very little is known about the relevance of 5-HT(7) receptors in behaviour. We here report that lack of 5-HT(7) receptors leads to a specific learning deficit that is not due to general sensory or behavioural deficits. The knockout mice show impaired contextual fear conditioning but no significant deficits in motor and spatial learning or cued and operant conditioning. In addition, we demonstrate that 5-HT(7) receptor knockout mice display decreased long-term synaptic plasticity within the CA1 region of the hippocampus. The results indicate an important role for the 5-HT(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus.

subject areas

  • Adaptation, Ocular
  • Animals
  • Conditioning (Psychology)
  • Conditioning, Operant
  • Cues
  • Dose-Response Relationship, Radiation
  • Electric Stimulation
  • Excitatory Postsynaptic Potentials
  • Fear
  • Hippocampus
  • Learning Disorders
  • Long-Term Potentiation
  • Male
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Neural Inhibition
  • Neurons
  • Pain Measurement
  • Psychomotor Performance
  • Receptors, Serotonin
  • Space Perception
  • Synapses
  • Visual Acuity
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Research

keywords

  • fear conditioning
  • knockout
  • learning and memory
  • long-term potentiation
  • serotonin receptor
  • synaptic plasticity
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Identity

International Standard Serial Number (ISSN)

  • 0953-816X

Digital Object Identifier (DOI)

  • 10.1111/j.1460.9568.2004.03288.x

PubMed ID

  • 15078565
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Additional Document Info

start page

  • 1913

end page

  • 1922

volume

  • 19

issue

  • 7

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