recent publications
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academic article
- Hu, J. K., Crampton, J. C., Cupo, A., Ketas, T., van Gils, M. J., Sliepen, K., de Taeye, S. W., Sok, D., Ozorowski, G., Deresa, I., Stanfield, R., Ward, A. B., et al. Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity Journal of Virology 2015 89:10383-10398 DOI:10.1128/jvi.01653-15 PMID:26246566 PMCID:PMC4580201
- Julien, J. P., Lee, J. H., Ozorowski, G., Hua, Y., Torrents de la Peña, A., de Taeye, S. W., Nieusma, T., Cupo, A., Yasmeen, A., Golabek, M., Pugach, P., Klasse, P. J., et al. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens Proceedings of the National Academy of Sciences of the United States of America 2015 112:11947-11952 DOI:10.1073/pnas.1507793112 PMID:26372963 PMCID:PMC4586835
- Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers Science 2015 349:aac4223 DOI:10.1126/science.aac4223 PMID:26089353 PMCID:PMC4498988
- Dosenovic, P., von Boehmer, L., Escolano, A., Jardine, J., Freund, N. T., Gitlin, A. D., McGuire, A. T., Kulp, D. W., Oliveira, T., Scharf, L., Pietzsch, J., Gray, M. D., et al. Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice Cell 2015 161:1505-1515 DOI:10.1016/j.cell.2015.06.003 PMID:26091035 PMCID:PMC4604566
- Pritchard, L. K., Vasiljevic, S., Ozorowski, G., Seabright, G. E., Cupo, A., Ringe, R., Kim, H. J., Sanders, R. W., Doores, K. J., Burton, D. R., Wilson, I. A., Ward, A. B., et al. Structural constraints determine the glycosylation of HIV-1 envelope trimers Cell Reports 2015 11:1604-1613 DOI:10.1016/j.celrep.2015.05.017 PMID:26051934 PMCID:PMC4555872
- Pugach, P., Ozorowski, G., Cupo, A., Ringe, R., Yasmeen, A., de Val, N., Derking, R., Kim, H. J., Korzun, J., Golabek, M., de los Reyes, K., Ketas, T. J., et al. A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene Journal of Virology 2015 89:3380-3395 DOI:10.1128/jvi.03473-14 PMID:25589637 PMCID:PMC4337520
- Derking, R., Ozorowski, G., Sliepen, K., Yasmeen, A., Cupo, A., Torres, J. L., Julien, J. P., Lee, J. H., van Montfort, T., de Taeye, S. W., Connors, M., Burton, D. R., et al. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer PLoS Pathogens 2015 11:e1004767 DOI:10.1371/journal.ppat.1004767 PMID:25807248 PMCID:PMC4373910
- Guttman, M., Cupo, A., Julien, J. P., Sanders, R. W., Wilson, I. A., Moore, J. P., Lee, K. K. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Nature Communications 2015 6:6144 DOI:10.1038/ncomms7144 PMID:25652336 PMCID:PMC4338595
- Garces, F., Sok, D., Kong, L., McBride, R., Kim, H. J., Saye-Francisco, K. F., Julien, J. P., Hua, Y., Cupo, A., Moore, J. P., Paulson, J. C., Ward, A. B., et al. Structural evolution of glycan recognition by a family of potent HIV antibodies Cell 2014 159:69-79 DOI:10.1016/j.cell.2014.09.009 PMID:25259921 PMCID:PMC4278586
- Murin, C. D., Julien, J. P., Sok, D., Stanfield, R. L., Khayat, R., Cupo, A., Moore, J. P., Burton, D. R., Wilson, I. A., Ward, A. B. Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy Journal of Virology 2014 88:10177-10188 DOI:10.1128/jvi.01229-14 PMID:24965454 PMCID:PMC4136306
- Guttman, M., Garcia, N. K., Cupo, A., Matsui, T., Julien, J. P., Sanders, R. W., Wilson, I. A., Moore, J. P., Lee, K. K. CD4-induced activation in a soluble HIV-1 Env trimer Structure 2014 22:974-984 DOI:10.1016/j.str.2014.05.001 PMID:24931470 PMCID:PMC4231881
- Yasmeen, A., Ringe, R., Derking, R., Cupo, A., Julien, J. P., Burton, D. R., Ward, A. B., Wilson, I. A., Sanders, R. W., Moore, J. P., Klasse, P. J. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits Retrovirology 2014 11:41 DOI:10.1186/1742-4690-11-41 PMID:24884783 PMCID:PMC4067080
- Blattner, C., Lee, J. H., Sliepen, K., Derking, R., Falkowska, E., de la Pena, A. T., Cupo, A., Julien, J. P., van Gils, M., Lee, P. S., Peng, W., Paulson, J. C., et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity 2014 40:669-680 DOI:10.1016/j.immuni.2014.04.008 PMID:24768348 PMCID:PMC4057017
- Doria-Rose, N. A., Schramm, C. A., Gorman, J., Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M., Staupe, R. P., Altae-Tran, H. R., et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Nature 2014 509:55-62 DOI:10.1038/nature13036 PMID:24590074 PMCID:PMC4395007
- Chung, N. P. Y., Matthews, K., Kim, H. J., Ketas, T. J., Golabek, M., de los Reyes, K., Korzun, J., Yasmeen, A., Sanders, R. W., Klasse, P. J., Wilson, I. A., Ward, A. B., et al. Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies Retrovirology 2014 11:33 DOI:10.1186/1742-4690-11-33 PMID:24767177 PMCID:PMC4032163
- Lyumkis, D., Julien, J. P., de Val, N., Cupo, A., Potter, C. S., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Carragher, B., Wilson, I. A., Ward, A. B. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer Science 2013 342:1484-1490 DOI:10.1126/science.1245627 PMID:24179160 PMCID:PMC3954647
- Julien, J. P., Cupo, A., Sok, D., Stanfield, R. L., Lyumkis, D., Deller, M. C., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A. Crystal structure of a soluble cleaved HIV-1 envelope trimer Science 2013 342:1477-1483 DOI:10.1126/science.1245625 PMID:24179159 PMCID:PMC3886632
- Ringe, R. P., Sanders, R. W., Yasmeen, A., Kim, H. J., Lee, J. H., Cupo, A., Korzun, J., Derking, R., van Montfort, T., Julien, J. P., Wilson, I. A., Klasse, P. J., et al. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Proceedings of the National Academy of Sciences of the United States of America 2013 110:18256-18261 DOI:10.1073/pnas.1314351110 PMID:24145402 PMCID:PMC3831437
- Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens 2013 9:e1003342 DOI:10.1371/journal.ppat.1003342 PMID:23658524 PMCID:PMC3642082
- Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology 2013 87:9873-9885 DOI:10.1128/jvi.01226-13 PMID:23824824 PMCID:PMC3754145
- Khayat, R., Lee, J. H., Julien, J. P., Cupo, A., Klasse, P. J., Sanders, R. W., Moore, J. P., Wilson, I. A., Ward, A. B. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers Journal of Virology 2013 87:9865-9872 DOI:10.1128/jvi.01222-13 PMID:23824817 PMCID:PMC3754114
- Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology 2013 20:796-803 DOI:10.1038/nsmb.2594 PMID:23708606 PMCID:PMC3823233
- Julien, J. P., Lee, J. H., Cupo, A., Murin, C. D., Derking, R., Hoffenberg, S., Caulfield, M. J., King, C. R., Marozsan, A. J., Klasse, P. J., Sanders, R. W., Moore, J. P., et al. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Proceedings of the National Academy of Sciences of the United States of America 2013 110:213-218 DOI:10.1073/pnas.1217537110 PMID:23426631 PMCID:PMC3600498
- Sanders, R. W., Derking, R., Cupo, A., Julien, J. P., Yasmeen, A., de Val, N., Kim, H. J., Blattner, C., de la Pena, A. T., Korzun, J., Golabek, M., de los Reyes, K., et al. A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies PLoS Pathogens 2013 9:e1003618 DOI:10.1371/journal.ppat.1003618 PMID:24068931 PMCID:PMC3777863
- Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry 2012 287:24239-24254 DOI:10.1074/jbc.M112.371898 PMID:22645128 PMCID:PMC3397850
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215