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Involvement of mu-opioid receptors in potentiation of apomorphine-induced climbing behavior by morphine: Studies using mu-opioid receptor gene knockout mice

Academic Article
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Overview

authors

  • Jang, Choon-Gon
  • Park, Y.
  • Tanaka, S.
  • Ma, T. E.
  • Loh, H. H.
  • Ho, I. K.

publication date

  • May 2000

journal

  • Molecular Brain Research  Journal

abstract

  • The present study examined the hypothesis that mu-opioid receptors contribute to a behavioral stimulation produced by stimulation of dopamine receptors by comparing responses in mu-opioid receptor knockout and wild type mice. Apomorphine-induced climbing behavior was augmented by 65%, in wild type mice, but not in mu-knockout, following subcutaneous administration of morphine (15 mg/kg). Moreover, pretreatment with either naloxone (an opioid receptor antagonist) or haloperidol (a mixed D(1)/D(2) receptor antagonist) eliminated the enhancement by morphine of climbing behavior in wild type mice. These results indicate that expression of mu-opioid receptors plays an important role in the enhancement of climbing behavior induced by the dopamine receptor agonist, apomorphine. Furthermore, this augmentation is mediated by interaction between dopamine and mu-opioid receptors.

subject areas

  • Analgesics, Opioid
  • Animals
  • Apomorphine
  • Brain Chemistry
  • Dopamine Agonists
  • Dopamine Antagonists
  • Drug Synergism
  • Haloperidol
  • Mice
  • Mice, Knockout
  • Morphine
  • Motor Activity
  • Naloxone
  • Narcotic Antagonists
  • Receptors, Opioid, mu
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Research

keywords

  • climbing behavior
  • dopamine receptor
  • knockout mice
  • morphine
  • mu-opioid receptor
  • naloxone
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Identity

International Standard Serial Number (ISSN)

  • 0169-328X

Digital Object Identifier (DOI)

  • 10.1016/s0169-328x(00)00094-2

PubMed ID

  • 10891603
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Additional Document Info

start page

  • 204

end page

  • 206

volume

  • 78

issue

  • 1-2

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