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Galanin-(1-15), but not galanin-(1-29), modulates 5-ht1a receptors in the dorsal hippocampus of the rat-brain - possible existence of galanin receptor subtypes

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Overview

authors

  • Hedlund, Peter
  • Finnman, U. B.
  • Yanaihara, N.
  • Fuxe, K.

publication date

  • 1994

journal

  • Brain Research  Journal

abstract

  • The aim of the present study was to evaluate whether galanin-(1-29) and galanin-(1-15) can modulate the 5-hydroxytryptamine1A (5-HT1A) receptors using [3H]8-OH-2-(di-n-propylamino)-tetralin ([3H]8-OH-DPAT) as a radioligand. Membrane preparations of the dorsal hippocampus, an area having the recently described [125I]galanin-(1-15) fragment binding sites, but having very few porcine [125I]galanin-(1-29) binding sites, were used. Galanin-(1-15) produced a concentration-dependent increase in the Kd value of [3H]8-OH-DPAT with a maximum effect of approximately 65% at 3 nM of galanin-(1-15), whereas galanin-(1-29) had no effect. This increase of the Kd value of [3H]8-OH-DPAT could be completely counteracted by the putative galanin antagonist M35 (1 nM). The Bmax values of [3H]8-OH-DPAT were not affected in any experiment. In conclusion, the present results give further evidence for the existence of a galanin receptor subtype mainly recognizing N-terminal galanin fragments, also having the ability to reduce the affinity of 5-HT1A receptors.

subject areas

  • Animals
  • Galanin
  • Hippocampus
  • Male
  • Peptide Fragments
  • Peptides
  • Radioligand Assay
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Galanin
  • Receptors, Gastrointestinal Hormone
  • Receptors, Serotonin
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(94)90271-2

PubMed ID

  • 7512426
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Additional Document Info

start page

  • 163

end page

  • 167

volume

  • 634

issue

  • 1

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