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Pulmonary immune-complex deposition in wegeners granulomatosis

Academic Article
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Overview

authors

  • Shasby, D. M.
  • Schwarz, M. I.
  • Forstot, J. Z.
  • Theofilopoulos, Argyrios
  • Kassan, S. S.

publication date

  • 1982

journal

  • Chest  Journal

abstract

  • Two male patients with pulmonary manifestations of Wegener's granulomatosis are presented. One had an elevated rheumatoid factor, and both had elevated levels of immunoglobulin E. Both demonstrated characteristic necrotizing granulomatous lesions on light microscopy of lung tissue. Immunohistologic analysis of lung tissue demonstrated a granular deposition of immunoglobulin G and complement. Raji cell assay of sera demonstrated elevated levels of circulating immune complexes in the sera of the one patient tested prior to any therapy. These findings support the hypothesis that immune complex deposition contributes to the pathogenesis of Wegener's granulomatosis.

subject areas

  • Adult
  • Aged
  • Complement C3
  • Fluorescent Antibody Technique
  • Granulomatosis with Polyangiitis
  • Humans
  • Immune Complex Diseases
  • Immunoglobulin G
  • Lung
  • Male
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Identity

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.81.3.338

PubMed ID

  • 6459914
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Additional Document Info

start page

  • 338

end page

  • 340

volume

  • 81

issue

  • 3

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