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Activating and anxiogenic effects of corticotropin releasing-factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone

Academic Article
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Overview

authors

  • Britton, K. T.
  • Lee, G.
  • Dana, R.
  • Risch, S. C.
  • Koob, George

publication date

  • October 1986

journal

  • Life Sciences  Journal

abstract

  • Central administration of corticotropin releasing factor (CRF) in rats produces pituitary-adrenal activation and a variety of "anxiogenic-like" effects. The present study was designed to explore the contribution of the peripheral pituitary-adrenocortical axis in mediating these CRF responses. Intraventricularly administered CRF produced suppression of responding in the conflict test and a marked locomotor activation. Neither behavioral effect was altered by the prior administration of dexamethasone in a dose that blocked pituitary-adrenal activation to CRF. These results support the hypothesis that behavioral effects of CRF are mediated by its action at central sites and not via an action on the pituitary-adrenocortical system.

subject areas

  • Animals
  • Anxiety
  • Brain
  • Conflict (Psychology)
  • Corticosterone
  • Corticotropin-Releasing Hormone
  • Dexamethasone
  • Injections, Intraventricular
  • Male
  • Motor Activity
  • Pituitary-Adrenal System
  • Rats
  • Rats, Inbred Strains
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(86)90189-x

PubMed ID

  • 3489874
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Additional Document Info

start page

  • 1281

end page

  • 1286

volume

  • 39

issue

  • 14

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