recent publications
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academic article
- Sanchez-Alavez, M., Nguyen, W., Mori, S., Moroncini, G., Viader, A., Nomura, D. K., Cravatt, B. F., Conti, B. Monoacylglycerol lipase regulates fever response PLoS One 2015 10:e0134437 DOI:10.1371/journal.pone.0134437 PMID:26287872 PMCID:PMC4543552
- Kohnz, R. A., Mulvihill, M. M., Chang, J. W., Hsu, K. L., Sorrentino, A., Cravatt, B. F., Bandyopadhyay, S., Goga, A., Nomura, D. K. Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer ACS Chemical Biology 2015 10:1624-1630 DOI:10.1021/acschembio.5b00053 PMID:25945974 PMCID:PMC4702252
- Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology 2015 10:925-932 DOI:10.1021/cb500893q PMID:25602368 PMCID:PMC4402257
- Dominguez, E., Galmozzi, A., Chang, J. W., Hsu, K. L., Pawlak, J., Li, W., Godio, C., Thomas, J., Partida, D., Niessen, S., O'Brien, P. E., Russell, A. P., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Nature Chemical Biology 2014 10:113-121 DOI:10.1038/nchembio.1429 PMID:24362705 PMCID:PMC3953460
- Cao, Z. X., Mulvihill, M. M., Mukhopadhyay, P., Xu, H., Erdelyi, K., Hao, E. K., Holovac, E., Hasko, G., Cravatt, B. F., Nomura, D. K., Pacher, P. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice Gastroenterology 2013 144:808-817 DOI:10.1053/j.gastro.2012.12.028 PMID:23295443 PMCID:PMC3608818
- Morrison, B. E., Marcondes, M. C. G., Nomura, D. K., Sanchez-Alavez, M., Sanchez-Gonzalez, A., Saar, I., Kim, K. S., Bartfai, T., Maher, P., Sugama, S., Conti, B. Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide Journal of Immunology 2012 189:5498-5502 DOI:10.4049/jimmunol.1102150 PMID:23169588 PMCID:PMC3545403
- Benjamin, D. I., Cravatt, B. F., Nomura, D. K. Global profiling strategies for mapping dysregulated metabolic pathways in cancer Cell Metabolism 2012 16:565-577 DOI:10.1016/j.cmet.2012.09.013 PMID:23063552 PMCID:PMC3539740
- Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., Cravatt, B. F. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation Science 2011 334:809-813 DOI:10.1126/science.1209200 PMID:22021672 PMCID:PMC3249428
- Ramesh, D., Ross, G. R., Schlosburg, J. E., Owens, R. A., Abdullah, R. A., Kinsey, S. G., Long, J. Z., Nomura, D. K., Sim-Selley, L. J., Cravatt, B. F., Akbarali, H. I., Lichtman, A. H. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice Journal of Pharmacology and Experimental Therapeutics 2011 339:173-185 DOI:10.1124/jpet.111.181370 PMID:21719468 PMCID:PMC3186294
- Kinsey, S. G., Nomura, D. K., O'Neal, S. T., Long, J. Z., Mahadevan, A., Cravatt, B. F., Grider, J. R., Lichtman, A. H. Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice Journal of Pharmacology and Experimental Therapeutics 2011 338:795-802 DOI:10.1124/jpet.110.175778 PMID:21659471 PMCID:PMC3164340
- Nomura, D. K., Lombardi, D. P., Chang, J. W., Niessen, S., Ward, A. M., Long, J. Z., Hoover, H. H., Cravatt, B. F. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer Chemistry & Biology 2011 18:846-856 DOI:10.1016/j.chembiol.2011.05.009 PMID:21802006 PMCID:PMC3149849
- Ahn, K., Smith, S. E., Liimatta, M. B., Beidler, D., Sadagopan, N., Dudley, D. T., Young, T., Wren, P., Zhang, Y. H., Swaney, S., Van Becelaere, K., Blankman, J. L., et al. Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain Journal of Pharmacology and Experimental Therapeutics 2011 338:114-124 DOI:10.1124/jpet.111.180257 PMID:21505060 PMCID:PMC3126636
- Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America 2011 108:6811-6816 DOI:10.1073/pnas.1015248108 PMID:21398589 PMCID:PMC3084096
- Nicolaou, K. C., Sanchini, S., Sarlah, D., Lu, G., Wu, T. R., Nomura, D. K., Cravatt, B. F., Cubitt, B., de la Torre, J. C., Hessell, A. J., Burton, D. R. Design, synthesis, and biological evaluation of a biyouyanagin compound library Proceedings of the National Academy of Sciences of the United States of America 2011 108:6715-6720 DOI:10.1073/pnas.1015258108 PMID:21245351 PMCID:PMC3084107
- Chang, J. W., Nomura, D. K., Cravatt, B. F. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis Chemistry & Biology 2011 18:476-484 DOI:10.1016/j.chembiol.2011.02.008 PMID:21513884 PMCID:PMC3119342
- Nomura, D. K., Dix, M. M., Cravatt, B. F. Activity-based protein profiling for biochemical pathway discovery in cancer Nature Reviews Cancer 2010 10:630-638 DOI:10.1038/nrc2901 PMID:20703252 PMCID:PMC3021511
- Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nature Neuroscience 2010 13:1113-1119 DOI:10.1038/nn.2616 PMID:20729846 PMCID:PMC2928870
- Kopp, F., Komatsu, T., Nomura, D. K., Trauger, S. A., Thomas, J. R., Siuzdak, G., Simon, G. M., Cravatt, B. F. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice Chemistry & Biology 2010 17:831-840 DOI:10.1016/j.chembiol.2010.06.009 PMID:20797612 PMCID:PMC2931592
- Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S. W., Cravatt, B. F. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Cell 2010 140:49-61 DOI:10.1016/j.cell.2009.11.027 PMID:20079333 PMCID:PMC2885975
- Long, J. Z., Nomura, D. K., Vann, R. E., Walentiny, D. M., Booker, L., Jin, X., Burston, J. J., Sim-Selley, L. J., Lichtman, A. H., Wiley, J. L., Cravatt, B. F. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo Proceedings of the National Academy of Sciences of the United States of America 2009 106:20270-20275 DOI:10.1073/pnas.0909411106 PMID:19918051 PMCID:PMC2787168
- Long, J. Z., Nomura, D. K., Cravatt, B. F. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism Chemistry & Biology 2009 16:744-753 DOI:10.1016/j.chembiol.2009.05.009 PMID:19635411 PMCID:PMC2867454
- Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E. Activation of the endocannabinoid system by organophosphorus nerve agents Nature Chemical Biology 2008 4:373-378 DOI:10.1038/nchembio.86 PMID:18438404 PMCID:PMC2597283
- Nomura, D. K., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification Toxicology and Applied Pharmacology 2008 228:42-48 DOI:10.1016/j.taap.2007.11.021 PMID:18164358 PMCID:PMC2423230
- Nomura, D. K., Durkin, K. A., Chiang, K. P., Quistad, G. B., Cravatt, B. F., Casida, J. E. Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions Chemical Research in Toxicology 2006 19:1142-1150 DOI:10.1021/tx060117m PMID:16978018 PMCID:PMC2512971
- Nomura, D. K., Leungt, D., Chiang, K. P., Quistad, G. B., Cravatt, B. F., Casida, J. E. A brain detoxifying enzyme for organophosphorus nerve poisons Proceedings of the National Academy of Sciences of the United States of America 2005 102:6195-6200 DOI:10.1073/pnas.0501915102 PMID:15840715 PMCID:PMC1087944