recent publications

• academic article

  • Kohnz, R. A., Mulvihill, M. M., Chang, J. W., Hsu, K. L., Sorrentino, A., Cravatt, B. F., Bandyopadhyay, S., Goga, A., Nomura, D. K. Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer ACS Chemical Biology  2015 10:1624-1630  DOI:10.1021/acschembio.5b00053  PMID:25945974  PMCID:PMC4702252
  • Sanchez-Alavez, M., Nguyen, W., Mori, S., Moroncini, G., Viader, A., Nomura, D. K., Cravatt, B. F., Conti, B. Monoacylglycerol lipase regulates fever response PLoS One  2015 10:e0134437  DOI:10.1371/journal.pone.0134437  PMID:26287872  PMCID:PMC4543552
  • Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology  2015 10:925-932  DOI:10.1021/cb500893q  PMID:25602368  PMCID:PMC4402257
  • Dominguez, E., Galmozzi, A., Chang, J. W., Hsu, K. L., Pawlak, J., Li, W., Godio, C., Thomas, J., Partida, D., Niessen, S., O'Brien, P. E., Russell, A. P., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Nature Chemical Biology  2014 10:113-121  DOI:10.1038/nchembio.1429  PMID:24362705  PMCID:PMC3953460
  • Cao, Z. X., Mulvihill, M. M., Mukhopadhyay, P., Xu, H., Erdelyi, K., Hao, E. K., Holovac, E., Hasko, G., Cravatt, B. F., Nomura, D. K., Pacher, P. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice Gastroenterology  2013 144:808-817  DOI:10.1053/j.gastro.2012.12.028  PMID:23295443  PMCID:PMC3608818
  • Morrison, B. E., Marcondes, M. C. G., Nomura, D. K., Sanchez-Alavez, M., Sanchez-Gonzalez, A., Saar, I., Kim, K. S., Bartfai, T., Maher, P., Sugama, S., Conti, B. Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide Journal of Immunology  2012 189:5498-5502  DOI:10.4049/jimmunol.1102150  PMID:23169588  PMCID:PMC3545403
  • Benjamin, D. I., Cravatt, B. F., Nomura, D. K. Global profiling strategies for mapping dysregulated metabolic pathways in cancer Cell Metabolism  2012 16:565-577  DOI:10.1016/j.cmet.2012.09.013  PMID:23063552  PMCID:PMC3539740
  • Chang, J. W., Nomura, D. K., Cravatt, B. F. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis Chemistry & Biology  2011 18:476-484  DOI:10.1016/j.chembiol.2011.02.008  PMID:21513884  PMCID:PMC3119342
  • Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:6811-6816  DOI:10.1073/pnas.1015248108  PMID:21398589  PMCID:PMC3084096
  • Ramesh, D., Ross, G. R., Schlosburg, J. E., Owens, R. A., Abdullah, R. A., Kinsey, S. G., Long, J. Z., Nomura, D. K., Sim-Selley, L. J., Cravatt, B. F., Akbarali, H. I., Lichtman, A. H. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice Journal of Pharmacology and Experimental Therapeutics  2011 339:173-185  DOI:10.1124/jpet.111.181370  PMID:21719468  PMCID:PMC3186294
  • Nicolaou, K. C., Sanchini, S., Sarlah, D., Lu, G., Wu, T. R., Nomura, D. K., Cravatt, B. F., Cubitt, B., de la Torre, J. C., Hessell, A. J., Burton, D. R. Design, synthesis, and biological evaluation of a biyouyanagin compound library Proceedings of the National Academy of Sciences of the United States of America  2011 108:6715-6720  DOI:10.1073/pnas.1015258108  PMID:21245351  PMCID:PMC3084107
  • Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., Cravatt, B. F. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation Science  2011 334:809-813  DOI:10.1126/science.1209200  PMID:22021672  PMCID:PMC3249428
  • Kinsey, S. G., Nomura, D. K., O'Neal, S. T., Long, J. Z., Mahadevan, A., Cravatt, B. F., Grider, J. R., Lichtman, A. H. Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice Journal of Pharmacology and Experimental Therapeutics  2011 338:795-802  DOI:10.1124/jpet.110.175778  PMID:21659471  PMCID:PMC3164340
  • Ahn, K., Smith, S. E., Liimatta, M. B., Beidler, D., Sadagopan, N., Dudley, D. T., Young, T., Wren, P., Zhang, Y. H., Swaney, S., Van Becelaere, K., Blankman, J. L., et al. Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain Journal of Pharmacology and Experimental Therapeutics  2011 338:114-124  DOI:10.1124/jpet.111.180257  PMID:21505060  PMCID:PMC3126636
  • Nomura, D. K., Lombardi, D. P., Chang, J. W., Niessen, S., Ward, A. M., Long, J. Z., Hoover, H. H., Cravatt, B. F. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer Chemistry & Biology  2011 18:846-856  DOI:10.1016/j.chembiol.2011.05.009  PMID:21802006  PMCID:PMC3149849
  • Nomura, D. K., Dix, M. M., Cravatt, B. F. Activity-based protein profiling for biochemical pathway discovery in cancer Nature Reviews Cancer  2010 10:630-638  DOI:10.1038/nrc2901  PMID:20703252  PMCID:PMC3021511
  • Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nature Neuroscience  2010 13:1113-1119  DOI:10.1038/nn.2616  PMID:20729846  PMCID:PMC2928870
  • Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S. W., Cravatt, B. F. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis Cell  2010 140:49-61  DOI:10.1016/j.cell.2009.11.027  PMID:20079333  PMCID:PMC2885975
  • Kopp, F., Komatsu, T., Nomura, D. K., Trauger, S. A., Thomas, J. R., Siuzdak, G., Simon, G. M., Cravatt, B. F. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice Chemistry & Biology  2010 17:831-840  DOI:10.1016/j.chembiol.2010.06.009  PMID:20797612  PMCID:PMC2931592
  • Long, J. Z., Nomura, D. K., Cravatt, B. F. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism Chemistry & Biology  2009 16:744-753  DOI:10.1016/j.chembiol.2009.05.009  PMID:19635411  PMCID:PMC2867454
  • Long, J. Z., Nomura, D. K., Vann, R. E., Walentiny, D. M., Booker, L., Jin, X., Burston, J. J., Sim-Selley, L. J., Lichtman, A. H., Wiley, J. L., Cravatt, B. F. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo Proceedings of the National Academy of Sciences of the United States of America  2009 106:20270-20275  DOI:10.1073/pnas.0909411106  PMID:19918051  PMCID:PMC2787168
  • Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E. Activation of the endocannabinoid system by organophosphorus nerve agents Nature Chemical Biology  2008 4:373-378  DOI:10.1038/nchembio.86  PMID:18438404  PMCID:PMC2597283
  • Nomura, D. K., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification Toxicology and Applied Pharmacology  2008 228:42-48  DOI:10.1016/j.taap.2007.11.021  PMID:18164358  PMCID:PMC2423230
  • Nomura, D. K., Durkin, K. A., Chiang, K. P., Quistad, G. B., Cravatt, B. F., Casida, J. E. Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions Chemical Research in Toxicology  2006 19:1142-1150  DOI:10.1021/tx060117m  PMID:16978018  PMCID:PMC2512971
  • Nomura, D. K., Leungt, D., Chiang, K. P., Quistad, G. B., Cravatt, B. F., Casida, J. E. A brain detoxifying enzyme for organophosphorus nerve poisons Proceedings of the National Academy of Sciences of the United States of America  2005 102:6195-6200  DOI:10.1073/pnas.0501915102  PMID:15840715  PMCID:PMC1087944