recent publications

• academic article

  • Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., et al. Discovery, synthesis, and structure-based optimization of a series of n-(tert-butyl)-2-(n-arylamido)-2-(pyridin-3-yl) acetamides (ml188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (sars-cov) 3cl protease Journal of Medicinal Chemistry  2013 56:534-546  DOI:10.1021/jm301580n  PMID:23231439  PMCID:PMC3569073
  • Yang, H., Pinello, C. E., Luo, J., Li, D., Wang, Y., Zhao, L. Y., Jahn, S. C., Saldanha, S. A., Planck, J., Geary, K. R., Ma, H., Law, B. K., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Molecular Cancer Therapeutics  2013 12:610-620  DOI:10.1158/1535-7163.mct-12-0930  PMID:23625935  PMCID:PMC3651759
  • Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) Bioorganic & Medicinal Chemistry Letters  2012 22:7135-7141  DOI:10.1016/j.bmcl.2012.09.074  PMID:23079522  PMCID:PMC3601546
  • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I. Small-molecule proteostasis regulators for protein conformational diseases Nature Chemical Biology  2012 8:185-196  DOI:10.1038/nchembio.763  PMID:22198733  PMCID:PMC3262058
  • Weide, T., Saldanha, S. A., Minond, D., Spicer, T. P., Fotsing, J. R., Spaargaren, M., Frere, J. M., Bebrone, C., Sharpless, K. B., Hodder, P. S., Fokin, V. V. NH-1,2,3-triazole-based inhibitors of the VIM-2 Metallo-beta-Lactamase: synthesis and structure-activity studies ACS Medicinal Chemistry Letters  2010 1:150-154  DOI:10.1021/ml900022q  PMID:20625539  PMCID:PMC2901175
  • Grimm, C., Jors, S., Saldanha, S. A., Obukhov, A. G., Pan, B. F., Oshima, K., Cuajungco, M. P., Chase, P., Hodder, P., Heller, S. Small molecule activators of TRPML3 Chemistry & Biology  2010 17:135-148  DOI:10.1016/j.chembiol.2009.12.016  PMID:20189104  PMCID:PMC2834294
  • Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology  2010 77:46-57  DOI:10.1124/mol.109.058677  PMID:19837904  PMCID:PMC2802430
  • Minond, D., Saldanha, S. A., Subramaniam, P., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., et al. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries Bioorganic & Medicinal Chemistry  2009 17:5027-5037  DOI:10.1016/j.bmc.2009.05.070  PMID:19553129  PMCID:PMC2759276
  • Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P., Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate Bioorganic & Medicinal Chemistry  2009 17:990-1005  DOI:10.1016/j.bmc.2008.03.004  PMID:18358729  PMCID:PMC3298815