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A dominant role for cd8+-t-lymphocyte selection in simian immunodeficiency virus sequence variation

Academic Article
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Overview

authors

  • O'Connor, D. H.
  • McDermott, A. B.
  • Krebs, K. C.
  • Dodds, E. J.
  • Miller, J. E.
  • Gonzalez, E. J.
  • Jacoby, T. J.
  • Yant, L.
  • Piontkivska, H.
  • Pantophlet, R.
  • Burton, Dennis
  • Rehrauer, W. M.
  • Wilson, N.
  • Hughes, A. L.
  • Watkins, D. I.

publication date

  • December 2004

journal

  • Journal of Virology  Journal

abstract

  • CD8(+) T lymphocytes (CD8-TL) select viral escape variants in both human immunodeficiency virus and simian immunodeficiency virus (SIV) infections. The frequency of CD8-TL viral escape as well as the contribution of escape to overall virus diversification has not been assessed. We quantified CD8-TL selection in SIV infections by sequencing viral genomes from 35 SIVmac239-infected animals at the time of euthanasia. Here we show that positive selection for sequences encoding 46 known CD8-TL epitopes is comparable to the positive selection observed for the variable loops of env. We also found that >60% of viral variation outside of the viral envelope occurs within recognized CD8-TL epitopes. Therefore, we conclude that CD8-TL selection is the dominant cause of SIV diversification outside of the envelope.

subject areas

  • Amino Acid Sequence
  • Animals
  • CD8-Positive T-Lymphocytes
  • Epitopes, T-Lymphocyte
  • Genetic Variation
  • Histocompatibility Antigens Class I
  • Macaca mulatta
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus
  • Viral Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.78.24.14012.14022.2004

PubMed ID

  • 15564508
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Additional Document Info

start page

  • 14012

end page

  • 14022

volume

  • 78

issue

  • 24

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