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Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

Academic Article
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Overview

related to degree

  • Johnson, Jeffrey R, Ph.D. in Biochemistry, Scripps Research 2002 - 2007

authors

  • Le Roch, K. G.
  • Johnson, Jeffrey R
  • Florens, L.
  • Zhou, Y. Y.
  • Santrosyan, A.
  • Grainger, M.
  • Yan, S. F.
  • Williamson, K. C.
  • Holder, A. A.
  • Carucci, D. J.
  • Yates III, John
  • Winzeler, Elizabeth

publication date

  • November 2004

journal

  • Genome Research  Journal

abstract

  • To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.

subject areas

  • Animals
  • Gene Expression Regulation
  • Genes, Protozoan
  • Life Cycle Stages
  • Plasmodium falciparum
  • Protozoan Proteins
  • RNA, Messenger
  • RNA, Protozoan
  • Transcription, Genetic
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Identity

PubMed Central ID

  • PMC525690

International Standard Serial Number (ISSN)

  • 1088-9051

Digital Object Identifier (DOI)

  • 10.1101/gr.2523904

PubMed ID

  • 15520293
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Additional Document Info

start page

  • 2308

end page

  • 2318

volume

  • 14

issue

  • 11

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