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Identification of four gene variants associated with myocardial infarction

Academic Article
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Overview

authors

  • Shiffman, D.
  • Ellis, S. G.
  • Rowland, C. M.
  • Malloy, M. J.
  • Luke, M. M.
  • Iakoubova, O. A.
  • Pullinger, C. R.
  • Cassano, J.
  • Aouizerat, B. E.
  • Fenwick, R. G.
  • Reitz, R. E.
  • Catanese, J. J.
  • Leong, D. U.
  • Zellner, C.
  • Sninsky, J. J.
  • Topol, Eric
  • Devlin, J. J.
  • Kane, J. P.

publication date

  • October 2005

journal

  • American Journal of Human Genetics  Journal

abstract

  • Family history is a major risk factor for myocardial infarction (MI). However, known gene variants associated with MI cannot fully explain the genetic component of MI risk. We hypothesized that a gene-centric association study that was not limited to candidate genes could identify novel genetic associations with MI. We studied 11,053 single-nucleotide polymorphisms (SNPs) in 6,891 genes, focusing on SNPs that could influence gene function to increase the likelihood of identifying disease-causing gene variants. To minimize false-positive associations generated by multiple testing, two studies were used to identify a limited number of nominally associated SNPs; a third study tested the hypotheses that these SNPs are associated with MI. In the initial study (of 340 cases and 346 controls), 637 SNPs were associated with MI (P<.05); these were evaluated in a second study (of 445 cases and 606 controls), and 31 of the 637 SNPs were associated with MI (P<.05) and had the same risk allele as in the first study. For each of these 31 SNPs, we tested the hypothesis that it is associated with MI, using a third study (of 560 cases and 891 controls). We found that four of these gene variants were associated with MI (P<.05; false-discovery rate <10%) and had the same risk allele as in the first two studies. These gene variants encode the cytoskeletal protein palladin (KIAA0992 [odds ratio (OR) 1.40]), a tyrosine kinase (ROS1 [OR 1.75]), and two G protein-coupled receptors (TAS2R50 [OR 1.58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles. These findings could lead to a better understanding of MI pathophysiology and improved patient risk assessment.

subject areas

  • Aged
  • Case-Control Studies
  • Female
  • Genetic Variation
  • Genotype
  • Humans
  • Likelihood Functions
  • Male
  • Middle Aged
  • Myocardial Infarction
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Identity

PubMed Central ID

  • PMC1275608

International Standard Serial Number (ISSN)

  • 0002-9297

Digital Object Identifier (DOI)

  • 10.1086/491674

PubMed ID

  • 16175505
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Additional Document Info

start page

  • 596

end page

  • 605

volume

  • 77

issue

  • 4

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