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Role of interleukin-7 in bone and t-cell homeostasis

Academic Article
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Overview

authors

  • Lee, S. K.
  • Surh, Charles

publication date

  • 2005

journal

  • Immunological Reviews  Journal

abstract

  • Initially defined as a B-cell growth factor, the pleiotropic nature of interleukin-7 (IL-7) has increasingly become appreciated. Besides its well-known roles in B- and T-cell lymphopoiesis, IL-7 is now known to regulate the homeostasis of both mature T cells and bone cells. In bone, the precise nature of how IL-7 affects osteoclasts and osteoblasts is controversial, since it has a variety of actions in different target cells. These activities are gender-specific and are dependent on whether IL-7 is delivered systemically or locally. In mature T cells, IL-7 is essential for the survival of nearly all subsets. Naïve T cells are also dependent on IL-7 for survival and homeostatic proliferation in response to lymphopenia. In addition, IL-7 plays a role in the survival of memory CD8+ cells, and at high concentrations, it can compensate for the absence of IL-15. The role of IL-7 on memory CD4+ cells remains controversial and has yet to be firmly established.

subject areas

  • Animals
  • B-Lymphocytes
  • Bone and Bones
  • Cell Survival
  • Homeostasis
  • Humans
  • Immunologic Memory
  • Interleukin-7
  • Lymphocyte Activation
  • Osteoclasts
  • Osteogenesis
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.0105-2896.2005.00339.x

PubMed ID

  • 16313348
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Additional Document Info

start page

  • 169

end page

  • 180

volume

  • 208

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