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Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy

Academic Article
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Overview

authors

  • Lasmezas, Corinne
  • Deslys, J. P.
  • Demaimay, R.
  • Adjou, K. T.
  • Hauw, J. J.
  • Dormont, D.

publication date

  • July 1996

journal

  • Journal of General Virology  Journal

abstract

  • The development of transmissible spongiform encephalopathies in experimental models depends on two major factors: the intracerebral accumulation of an abnormal, protease-resistant isoform of PrP (PrPres), which is a host protein mainly expressed in neurons; and the existence of different strains of agent. In order to make a distinction between pathogenic mechanisms depending upon the accumulation of host-derived PrPres and the strain-specific effects, we quantified and compared the sequence of molecular [PrPres and glial fibrillary acidic protein (GFAP) accumulation] and pathological events in the brains of syngeneic mice throughout the course of infection with two different strains of agent. The bovine spongiform encephalopathy (BSE) agent exhibits properties different from any known scrapie source and has been studied in comparison with a classical scrapie strain. Convergent kinetic data in both models confirmed the cause-effect relationship between PrPres and pathological changes and showed that PrPres accumulation is directly responsible for astrocyte activation in vivo. Moreover, we observed a threshold level of PrPres for this effect on astroglial cells. However, despite similar infectivity titres, the BSE model produced less PrPres than scrapie, and the relative importance of gliosis was higher. The comparison of the molecular and pathological features after intracerebral or intraperitoneal inoculation also revealed differences between the models. Therefore, the mechanisms leading to the targeting and the fine regulation of the molecular events seem to be independent of the host PrP and to depend upon the agent. The possible involvement of a regulatory molecule accounting for these specificities has to be considered.

subject areas

  • Animals
  • Astrocytes
  • Cattle
  • Disease Models, Animal
  • Encephalopathy, Bovine Spongiform
  • Glial Fibrillary Acidic Protein
  • Mice
  • Mice, Inbred C57BL
  • PrPSc Proteins
  • Scrapie
  • Sheep
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0022-1317

Digital Object Identifier (DOI)

  • 10.1099/0022-1317-77-7-1601

PubMed ID

  • 8758005
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Additional Document Info

start page

  • 1601

end page

  • 1609

volume

  • 77

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