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DNA double-strand break repair from head to tail

Academic Article
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Overview

authors

  • Hopfner, K. P.
  • Putnam, Christopher
  • Tainer, John

publication date

  • February 2002

journal

  • Current Opinion in Structural Biology  Journal

abstract

  • DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

subject areas

  • Adenosine Triphosphate
  • Antigens, Nuclear
  • Archaeal Proteins
  • DNA
  • DNA Helicases
  • DNA Repair
  • DNA-Binding Proteins
  • Endodeoxyribonucleases
  • Exodeoxyribonucleases
  • Nuclear Proteins
  • Protein Conformation
  • Saccharomyces cerevisiae Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0959-440X

Digital Object Identifier (DOI)

  • 10.1016/s0959-440x(02)00297-x

PubMed ID

  • 11839498
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Additional Document Info

start page

  • 115

end page

  • 122

volume

  • 12

issue

  • 1

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