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Galanin, galanin receptors, and drug targets

Academic Article
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Overview

authors

  • Mitsukawa, K.
  • Lu, X.
  • Bartfai, Tamas

publication date

  • 2010

journal

  • Experientia  Journal

abstract

  • Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Over the past decade, some of the receptor subtype-specific effects have been elucidated through pharmacological studies using subtype selective ligands, as well as through molecular approaches involving knockout animals. In this chapter, we summarize the current data which constitute the basis of targeting GalR1, GalR2, and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.

subject areas

  • Affect
  • Alcohol Drinking
  • Alzheimer Disease
  • Animals
  • Cognition
  • Feeding Behavior
  • Galanin
  • Humans
  • Ligands
  • Neoplasms
  • Pain
  • Receptors, Galanin
  • Seizures
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Identity

International Standard Serial Number (ISSN)

  • 1023-294X (Print) 1023-294X (Linking)

Digital Object Identifier (DOI)

  • 10.1007/978-3-0346-0228-0_2

PubMed ID

  • 21299058
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Additional Document Info

start page

  • 7

end page

  • 23

volume

  • 102

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