recent publications

• academic article

  • Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., Janda, K. D. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity Chemical Communications  2015 51:6226-6229  DOI:10.1039/c5cc00677e  PMID:25759983
  • Seki, H., Pellett, S., Silhar, P., Stowe, G. N., Blanco, B., Lardy, M. A., Johnson, E. A., Janda, K. D. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain Bioorganic & Medicinal Chemistry  2014 22:1208-1217  DOI:10.1016/j.bmc.2013.11.053  PMID:24360826  PMCID:PMC3919520
  • Silhar, P., Eubanks, L. M., Seki, H., Pellet, S., Javor, S., Tepp, W. H., Johnson, E. A., Janda, K. D. Targeting botulinum A cellular toxicity: a prodrug approach Journal of Medicinal Chemistry  2013 56:7870-7879  DOI:10.1021/jm400873n  PMID:24127873  PMCID:PMC3880648