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Innate immune sensing and its roots: the story of endotoxin

Academic Article
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Overview

authors

  • Beutler, Bruce
  • Rietschel, E. T.

publication date

  • February 2003

journal

  • Nature Reviews Immunology  Journal

abstract

  • How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors--the Toll-like receptors--was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.

subject areas

  • Drosophila Proteins
  • Endotoxins
  • History, 18th Century
  • History, 19th Century
  • History, 20th Century
  • History, Ancient
  • Immunity, Innate
  • Lipopolysaccharides
  • Macrophages
  • Membrane Glycoproteins
  • Models, Immunological
  • Receptors, Cell Surface
  • Signal Transduction
  • Toll-Like Receptors
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Identity

International Standard Serial Number (ISSN)

  • 1474-1733

Digital Object Identifier (DOI)

  • 10.1038/nri1004

PubMed ID

  • 12563300
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Additional Document Info

start page

  • 169

end page

  • 176

volume

  • 3

issue

  • 2

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