Q-bodies monitor the quinary state of the protein fold

Academic Article

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Overview

authors

• Roth, D. M.
• Balch, William E.

publication date

• October 2013

journal

• Nature Cell Biology  Journal

abstract

• Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.

subject areas

• Animals
• Heat-Shock Proteins
• Humans
• Protein Folding
• Protein Stability
• Proteins
• Proteolysis
• Signal Transduction

Identity

International Standard Serial Number (ISSN)

• 1465-7392

Digital Object Identifier (DOI)

• 10.1038/ncb2857

PubMed ID

• 24084862

Additional Document Info

start page

• 1137

end page

• 1139

volume

• 15

issue

• 10