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Q-bodies monitor the quinary state of the protein fold

Academic Article
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Overview

authors

  • Roth, D. M.
  • Balch, William E.

publication date

  • October 2013

journal

  • Nature Cell Biology  Journal

abstract

  • Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.

subject areas

  • Animals
  • Heat-Shock Proteins
  • Humans
  • Protein Folding
  • Protein Stability
  • Proteins
  • Proteolysis
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 1465-7392

Digital Object Identifier (DOI)

  • 10.1038/ncb2857

PubMed ID

  • 24084862
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Additional Document Info

start page

  • 1137

end page

  • 1139

volume

  • 15

issue

  • 10

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